Phenylsulfonylureas, Processes for their-preparation, and their use as herbicides and plant growth regulators

ABSTRACT

Compounds of the formula (I) and their salts as defined below, &lt;IMAGE&gt; (I)  in which R1 is CO-Q-R8, where R8=H or R R2 and R3 are H or (C1-C4)alkyl, R4 is H, R, RO, OH, RCO, RSO2, PhSO2 R5 is RSO2, PhSO2, PhCO, RNHSO2, R2NSO2, RCO, CHO, COCOR&#39;, CW-T-R9, CW-NR10R11, CW-N(R12)2 or R4 and R5 together are the chain (CH2)mB or -B1-(CH2)m1B- where B=SO2, CO; m=3, 4; m1=2, 3; T and W=O, S; Q=O, S, NR13 where R13=H, R; R6=H, R, RO, RCO, ROCO, Hal, NO2, CN; R7=H, CH3; R9=R; R10, R11=H, R; N(R12)2=heterocycle A=pyrimidinyl and triazinyl radical or an analog thereof, where R=(substituted) aliphatic hydrocarbon radical, are suitable as selective herbicides. They are prepared by analogous processes via sulfonamides.

It is known that some phenylsulfonylureas possess herbicidal and plant growth-regulating properties; cf. U.S. Pat. No. 4,786,314, U.S. Pat. No. 4,927,453 and WO 89/10921. However in some cases these phenylsulfonylureas have disadvantages in use, for example a high persistence or inadequate selectivity in important crops.

Phenylsulfonylureas having specific radicals on the phenyl ring have now been found which can be employed advantageously as herbicides and plant growth regulators.

The present invention relates to compounds of the formula (I) or their salts, ##STR2## in which R¹ is CO--Q--R⁸,

R² and R³ independently of one another are H or (C₁ -C₄)alkyl,

R₄ is H, (C₁ -C₈)alkyl which is unsubstituted or is substituted by one or more radicals from the group consisting of halogen, (C₁ -C₄)alkoxy, (C₁ -C₄)alkylthio, (C₁ -C₄)alkylsulfinyl, (C₁ -C₄)alkylsulfonyl, [(C₁ -C₄)alkoxy]carbonyl and CN, or is (C₃ -C₆)alkenyl which is unsubstituted or is substituted by one or more halogen atoms, or is (C₃ -C₆)alkynyl which is unsubstituted or is substituted by one or more halogen atoms, or is hydroxyl, (C₁ -C₄)alkoxy, [(C₁ -C₄)alkyl]carbonyl or (C₁ -C₄)alkylsulfonyl, each of the three latter radicals being unsubstituted or substituted in the alkyl moiety by one or more halogen atoms or by (C₁ -C₄)alkoxy or (C₁ -C₄)alkylthio, or is phenylsulfonyl in which the phenyl radical is unsubstituted or substituted, preferably by one or more radicals from the group consisting of halogen, CN, NO₂, (C₁ -C₄)alkyl, (C₁ -C₄)haloalkyl and (C₁ -C₄)alkoxy, and

R⁵ is (C₁ -C₄)alkylsulfonyl or (C₃ -C₆)alkenylsulfonyl, each of the two latter radicals being unsubstituted or substituted by one or more halogen atoms or by (C₁ -C₄)alkoxy or (C₁ -C₄)alkylthio, or is phenylsulfonyl or phenylcarbonyl, the phenyl radical in each of the two latter radicals being unsubstituted or substituted, preferably by one or more radicals from the group consisting of halogen, CN, NO₂, (C₁ -C₄)alkyl, (C₁ -C₄)haloalkyl and (C₁ -C₄)alkoxy, or is mono- or di-[(C₁ -C₄)alkyl]aminosulfonyl or [(C₁ -C₆)alkyl]carbonyl, each of the three latter radicals being unsubstituted or substituted by one or more radicals from the group consisting of halogen, (C₁ -C₄)alkoxy, (C₁ -C₄)alkylthio, (C₁ -C₄)alkylsulfinyl, (C₁ -C₄)alkylsulfonyl, [(C₁ -C₄)alkyl]carbonyl, [(C₁ -C₄)alkoxy]carbonyl and CN, or is formyl, a group of the formula --CO--CO--R' in which R'═H, OH, (C₁ -C₄)alkoxy or (C₁ -C₄)alkyl, or is [(C₃ -C₆)cycloalkyl]carbonyl, [(C₂ -C₆)alkenyl]carbonyl or [(C₂ -C₆)alkynyl]carbonyl, each of the three latter radicals being unsubstituted or substituted by one or more halogen atoms, or is a group of the formula ##STR3## or R⁴ and R⁵ together are a chain of the formula (--CH₂)_(m) B-- or --B¹ --(CH₂)_(m1) --B--, the chain being unsubstituted or substituted by one or more, preferably up to four, (C₁ -C₃)alkyl radicals and m being 3 or 4 or m¹ being 2 or 3, and

W is an oxygen or sulfur atom (i.e. O or S),

B and B¹ independently of one another are SO₂ or CO,

Q is O, S or --NR¹³ --,

T is O or S,

R⁶ is H, (C₁ -C₄)alkyl, (C₁ -C₄)alkoxy, [(C₁ -C₄)alkyl]carbonyl or [(C₁ -C₄)alkoxy]carbonyl, each of the 4 latter radicals being unsubstituted or substituted in the alkyl moiety by one or more halogen atoms, or is halogen, NO₂ or CN,

R⁷ is H or CH₃,

R⁸ is H, (C₁ -C₄)alkyl, (C₃ -C₄)alkenyl or (C₃ -C₄)alkynyl, each of the three latter radicals being unsubstituted or substituted by one or more radicals from the group consisting of halogen, (C₁ -C₄)alkoxy, (C₁ -C₄)alkylthio, [(C₁ -C₄)alkyl]carbonyl and [(C₁ -C₄)alkoxy]carbonyl,

R⁹ is (C₁ -C₄)alkyl, (C₃ -C₄)alkenyl or (C₃ -C₄)alkynyl, each of the three latter radicals being unsubstituted or substituted by one or more radicals from the group consisting of halogen, (C₁ -C₄)alkoxy, (C₁ -C₄)alkylthio, [(C₁ -C₄)alkyl]carbonyl and [(C₁ -C₄)alkoxy]carbonyl,

R¹⁰ and R¹¹ independently of one another are H, (C₁ -C₄) alkyl, (C₃ -C₄)alkenyl or (C₃ -C₄)alkynyl, each of the three latter radicals being unsubstituted or substituted by one or more radicals from the group consisting of halogen, (C₁ -C₄)alkoxy, (C₁ -C₄)alkylthio, [(C₁ -C₄)alkyl]carbonyl and [(C₁ -C₄)alkoxy]carbonyl,

the radicals R¹² together with the nitrogen atom are a heterocyclic ring having 5 or 6 ring members, which may contain further heteroatoms from the group consisting of N, O and S in the possible oxidation states and is unsubstituted or is substituted by (C₁ -C₄)alkyl or the oxo group, or is benzo-fused,

R¹³ is H, (C₁ -C₄)alkyl, (C₃ -C₄)alkenyl or (C₃ -C₄)alkynyl, each of the three latter radicals being unsubstituted or substituted by one or more radicals from the group consisting of halogen, (C₁ -C₄)alkoxy and (C₁ -C₄)alkylthio,

A is a radical of the formula ##STR4## one of the radicals X and Y is hydrogen, halogen, (C₁ -C₃)alkyl or (C₁ -C₃)alkoxy, the two latter radicals being unsubstituted or being mono- or polysubstituted by halogen or monosubstituted by (C₁ -C₃)alkoxy, and

the other of the radicals X and Y is hydrogen, (C₁ -C₃)alkyl, (C₁ -C₃)alkoxy or (C₁ -C₃)alkylthio, the three latter alkyl-containing radicals being unsubstituted or mono- or polysubstituted by halogen or mono- or disubstituted by (C₁ -C₃)alkoxy or (C₁ -C₃)alkylthio, or is a radical of the formula NR¹⁴ R¹⁵, (C₃ -C₆)cycloalkyl, (C₂ -C₄)alkenyl, (C₂ -C₄)alkynyl, (C₃ -C₄)alkenyloxy or (C₃ -C₄)alkynyloxy,

Z is CH or N,

R¹⁴ and R¹⁵ independently of one another are H, (C₁ -C₃)alkyl or (C₃ -C₄)alkenyl,

X¹ is CH₃, OCH₃, OC₂ H₅ or OCHF₂,

Y¹ is --O-- or --CH₂ --,

X² is CH₃, C₂ H₅ or CH₂ CF₃,

Y² is OCH₃, OC₂ H₅, SCH₃, SCH₂ CH₃, CH₃ or C₂ H₅,

X³ is CH₃ or OCH₃,

Y³ is H or CH₃,

X⁴ is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃ or Cl,

Y⁴ is CH₃, OCH₃, OC₂ H₅ or Cl, and

Y⁵ is CH₃, C₂ H₅, OCH₃ or Cl.

In the formula (I) and below, alkyl, alkoxy, haloalkyl, alkylamino and alkylthio radicals as well as the corresponding unsaturated and/or substituted radicals in the carbon framework may in each case be straight-chain or branched. Alkyl radicals, alone or in composite definitions such as alkoxy, haloalkyl etc., are methyl, ethyl, n- or i-propyl, n-, i-, t- or 2-butyl; alkenyl and 2alkynyl radicals have the definition of the possible unsaturated radicals corresponding to the alkyl radicals, such as 2-propenyl, 2- or 3-butenyl, 2-propynyl, or 2- or 3-butynyl. Halogen is fluorine, chlorine, bromine or iodine; haloalkyl is alkyl which is substituted by one or more atoms from the group consisting of halogen; examples of haloalkyl are CF₃, CHF₂ and CH₂ CF₃. Substituted phenyl is advantageously phenyl which is substituted by one or more, preferably 1, 2 or 3, radicals from the group consisting of halogen, such as F, Cl, Br and I, preferably F, Cl and Br, and also alkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyl, amino, nitro, cyano, alkoxycarbonyl, alkylcarbonyl, formyl, carbamoyl, mono- and dialkylaminocarbonyl, mono- and dialkylamino, alkylsulfinyl and alkylsulfonyl, and, for radicals containing carbon atoms, those having from 1 to 4 carbon atoms, especially 1 or 2, are preferred. In this context preference is generally given to substituents from the group consisting of halogen, for example fluorine and chlorine, C₁ -C₄ -alkyl, preferably methyl or ethyl, C₁ -C₄ -haloalkyl, preferably trifluoromethyl, C₁ -C₄ -alkoxy, preferably methoxy or ethoxy, C₁ -C₄ -haloalkoxy, nitro and cyano.

A 5- or 6-membered heterocyclic radical which may if desired be benzo-fused and which contains a nitrogen atom (e.g. in the case of N(R¹²)₂) may be a saturated, unsaturated or heteroaromatic radical, for example a radical which is attached via the nitrogen atom and is selected from the group consisting of pyrrolidinyl, piperidyl, pyrazolyl, morpholinyl, indolyl, quinolyl, pyrimidinyl, triazolyl, oxazolyl, pyridyl, pyridazinyl, pyrazinyl, thiazolyl, pyrrolyl, imidazolyl and benzoxazolyl.

The invention also relates to all the stereoisomers encompassed by formula (I), and to mixtures thereof. Such compounds of the formula (I) contain one or more asymmetric carbon atoms or double bonds which are not indicated specifically in the formula (I). Formula (I) encompasses all of the possible stereoisomers defined by their specific spatial orientation such as enantiomers, diastereomers, Z and E isomers, all of which can be prepared by conventional methods from mixtures of the stereoisomers or else by stereoselective reactions in combination with the use of stereochemically pure starting materials.

The compounds of the formula (I) may form salts in which the hydrogen of the --SO₂ --NH-group is replaced by a cation which is suitable for agriculture. Examples of these salts are metal salts, in particular alkali metal salts or alkaline earth metal salts, especially sodium and potassium salts, or alternatively ammonium salts or salts with organic amines.

Of particular interest are compounds of the formula (I) according to the invention or their salts in which

R⁴ is H, (C₁ -C₄)alkyl, which is unsubstituted or is substituted by one or more radicals from the group consisting of halogen, (C₁ -C₄)alkoxy, (C₁ -C₄)alkylthio, (C₁ -C₄)alkylsulfonyl, [(C₁ -C₄)alkoxy]carbonyl and CN, or is (C₃ -C₄)alkenyl, (C₃ -C₄)alkynyl, hydroxyl, (C₁ -C₄)alkoxy, [(C₁ -C₄)alkyl]carbonyl or (C₁ -C₄)alkylsulfonyl, each of the five latter radicals being unsubstituted or substituted in the alkyl moiety by one or more halogen atoms, or is phenylsulfonyl in which the phenyl radical is unsubstituted or is substituted by one or more radicals from the group consisting of halogen, (C₁ -C₄)alkyl and (C₁ -C₄)alkoxy, and

R⁵ is (C₁ -C₄)alkylsulfonyl, (C₁ -C₄)haloalkylsulfonyl, phenylsulfonyl or phenylcarbonyl, the phenyl radical in the two latter radicals being unsubstituted or substituted by one or more radicals from the group consisting of halogen, (C₁ -C₄)alkyl and (C₁ -C₄)alkoxy, or is mono- or di-[(C₁ -C₄)alkyl]aminosulfonyl, [(C₁ -C₆)alkyl]carbonyl which is unsubstituted or is substituted by one or more halogen atoms or by (C₁ -C₄)alkoxy and (C₁ -C₄)alkylthio, or is formyl, OHC--CO--, 2-oxo-(C₃ -C₅)alkanoyl, [(C₁ -C₄)alkoxy]oxalyl, [(C₃ -C₆)cycloalkyl]carbonyl, [(C₂ -C₄)alkenyl]carbonyl or [(C₂ -C₄)alkynyl]carbonyl or is a group of the formula ##STR5## W is O or S, R⁶ is H, (C₁ -C₄)alkyl, (C₁ -C₄)haloalkyl, (C₁ -C₄)alkoxy, (C₁ -C₄)haloalkoxy or halogen,

R⁸ is at each occurrence (C₁ -C₄)alkyl which is unsubstituted or is substituted by one or more halogen atoms, or is (C₃ -C₄)alkenyl or (C₃ -C₄)alkynyl,

R⁹ is H, (C₁ -C₄)alkyl which is unsubstituted or is substituted by one or more halogen atoms or by (C₁ -C₄)alkoxy, (C₁ -C₄)alkylthio, [(C₁ -C₄)alkoxy]carbonyl and [(C₁ -C₄)alkyl]carbonyl,

R¹⁰ and R¹¹ independently of one another are H, (C₁ -C₄)alkyl which is unsubstituted or is substituted by one or more halogen atoms, or are (C₃ -C₄)alkenyl or (C₃ -C₄)alkynyl, at least one of the radicals R¹⁰ and R¹¹ being different from hydrogen,

the radicals R¹² together with the nitrogen atom are a heterocyclic ring having 5 or 6 ring members, which may contain a further heteroatom from the group consisting of N, O and S in the various oxidation states and is unsubstituted or is substituted by (C₁ -C₄)alkyl or by the oxo group, and

R¹³ is at each occurrence H, (C₁ -C₄)alkyl which is unsubstituted or is substituted by one or more halogen atoms, or is (C₃ -C₄)alkenyl or (C₃ -C₄)alkynyl.

Preferred compounds of the formula (I) or their salts are those in which W is an oxygen atom and A is a radical of the formula ##STR6## in which X, Y and Z are defined as described above.

Particularly preferred compounds of the formula (I) or their salts are those in which

R⁴ is H, (C₁ -C₄)alkyl, hydroxyl or (C₁ -C₄)alkoxy,

R⁵ is (C₁ -C₄)alkylsulfonyl, CHO, [(C₁ -C₄)alkyl]carbonyl which is unsubstituted or is substituted by one or more halogen atoms, or is [(C₁ -C₄)alkoxy]oxalyl, [(C₃ -C₆)cycloalkyl]carbonyl or a group of the formula ##STR7## in which W, T and R⁹ to R¹² are as defined above for formula (I),

R⁶ is H, (C₁ -C₃)alkyl, (C₁ -C₃)alkoxy or halogen,

A is a radical of the formula ##STR8## Z is CH or N, preferably CH, and one of the radicals X and Y is halogen, (C₁ -C₂)alkyl, (C₁ -C₂)alkoxy, OCF₂ H, CF₃ or OCH₂ CF₃ and the other of the radicals X and Y is (C₁ -C₂)alkyl, (C₁ -C₂)alkoxy or (C₁ -C₂)haloalkoxy.

For reasons of increased ease of preparation or of better biological action, compounds of the formula (II) according to the invention or their salts in which the group --CR² R³ --NR⁴ R⁵ is in the ortho or para position to the group R¹ or is in the ortho position to the sulfo group are of particular interest; the preferred position of the group --CR² R³ --NR⁴ R⁵ is para to the group R¹.

The present invention also relates to processes for the preparation of the compounds of the formula (I) or their salts, which comprise

a) reacting a compound of the formula (II) ##STR9## with a heterocyclic carbamate of the formula (III)

    R*--O--CO--NR.sup.7 --A                                    (III)

in which R* is unsubstituted or substituted phenyl or (C₁ -C₄)alkyl, or

b) reacting a phenyl sulfonylcarbamate of the formula (IV) ##STR10## with an amino heterocycle of the formula (V)

    H--NR.sup.7 --A                                            (V)

or

c) reacting a sulfonyl isocyanate of the formula (VI) ##STR11## with an amino heterocycle of the formula H--NR⁷ --A (V), or d) in a one-pot reaction, first reacting an amino heterocycle of the formula H--NR⁷ --A (V) with phosgene in the presence of a base and reacting the intermediate formed with a phenyl sulfonamide of the formula (II), or

e) reacting a sulfonyl chloride of the formula (VII) ##STR12## with a cyanate M--OCN in which M═NH₄, Na or K, and with an amino heterocycle of the formula H--NR⁷ --A (V) in the presence of a base, or

f) reacting a sulfonamide of the above-mentioned formula (II) with a (thio)isocyanate of the formula (V')

    W═C═N--A                                           (V')

in the presence of a base,

the radicals and groups R¹ to R⁷, A and W in the formulae (II)-(VII) and (V') being as defined for formula (I) and, in variant a)-e), compounds of the formula (I) where W═O being obtained initially.

The reaction of the compounds of the formulae (II) and (III) is preferably carried out base-catalyzed in an inert organic solvent, for example dichloromethane, acetonitrile, dioxane or THF, at temperatures of between 0° C. and the boiling point of the solvent. Examples of the base used are organic amine bases, such as 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), especially when R*=(substituted) phenyl (cf. EP-A-44 807), or trimethylaluminum or triethylaluminum, the latter especially when R*=alkyl (cf. EP-A-166 516).

The sulfonamides (II) are new compounds. They and their preparation are also subjects of this invention.

Taking as example the compound (II) where R² ═R³ ═H and Q═O, possibilities for preparation are illustrated in more detail below, and with slight modifications can also be employed for compounds where R² and R³ are other than hydrogen and/or Q is other than O.

Starting from substituted or unsubstituted methylanilinesulfonic acids (VIII) (see German Imperial Patent 48 583, p. 242), which may be initially converted by diazotization and Sandmeyer reaction with KCN/CuCN into the nitriles (IX), the sulfonamide (X) is obtained as intermediate product after hydrolysis of the nitrile, esterification of the carboxyl group and conversion of the sulfo group into the tert-butyl-protected sulfonamide group by analogy with methods known from the literature (see Scheme 1). ##STR13##

Furthermore, sulfonamides (X) are obtained starting from substituted or unsubstituted methylnitrobenzoic acids (XI) via esterification, reduction of the nitro group, diazotization and coupling with SO₂ /CuCl (see H. Meerwein et al., Chem. Ber. 90, 841-1178 (1957)) and aminolysis with tert.-butylamine (see Scheme 2). ##STR14##

Likewise, sulfonamides (X) can be prepared starting from substituted or unsubstituted methylnitroanilines (XII). Diazotization and coupling with KCN/CuCN give the corresponding nitriles, which can be converted by hydrolysis of the cyano group and esterification into nitrobenzoic esters (XIII).

The nitro group can then as described for Scheme 2 be converted into the tert.-butylaminosulfonyl group (see Scheme 3). ##STR15##

For the preparation of the sulfonamides (II) compounds of the formula (X) are reacted by side-chain halogenation to give (XIV), then by substitution of the halogen atom in (XIV) for amines or azide, with subsequent reduction to give benzylamines (XV') and further functionalization of the amino group, and elimination of the tert.-butyl protecting group by analogy with a known procedure (for example with CF₃ COOH) to give the sulfonamides (II') (see Scheme 4). ##STR16##

The procedure can also be used analogously to prepare other compounds of the formula (II), employing in the final step the compound of the formula (XV). ##STR17##

The carbamates of the formula (III) can be prepared by methods which are described in South African Patent Applications 82/5671 and 82/5045 or EP-A-70 804 (U.S. Pat. No. 4,480,101) or RD 275 056.

The reaction of the compounds (IV) with the amino heterocycles (V) is preferably carried out in inert aprotic solvents such as dioxane, acetonitrile or tetrahydrofuran at temperatures of between 0° C. and the boiling temperature of the solvent. The required starting materials (V) are known from the literature or can be prepared by processes known from the literature. The phenylsulfonyl carbamates of the formula (IV) are obtained by analogy with U.S. Pat. No. 4,684,393 or U.S. Pat. No. 4,743,290.

The phenylsulfonyl isocyanates of the formula (VI) can be prepared by analogy with U.S. Pat. No. 4,481,029 and can be reacted with amino heterocycles (V).

The phosgenation of compounds of the formula (V) in accordance with variant d) can preferably be carried out in the presence of bases such as sterically hindered organic amine bases, for example triethylamine. The subsequent reaction with compounds of the formula (II) in accordance with variant d) can be carried out by analogy with known methods (cf. EP-A-232 067).

The sulfochlorides (VII) can be obtained from corresponding sulfonic acids by, for example, standard methods such as the reaction of the potassium salt with phosphorus oxychloride or thionyl chloride in inert solvents such as acetonitrile and/or sulfolane or in bulk by heating at reflux (cf. Houben-Weyl-Klamann, "Methoden der organischen Chemie", [Methods of Organic Chemistry], 4th edition, vol. E XI/2, pp. 1067-1073, Thieme Verlag, Stuttgart, 1985).

The corresponding sulfonic acids are obtainable from appropriate nitro compounds by analogy with the reaction of compounds (XI).

Alternatively, in individual cases sulfochlorides (VII) can be prepared by sulfonation (+chlorination) or sulfochlorination of appropriate substituted benzoic esters; sulfochlorination by analogy with Houben-Weyl-Klamann, "Methoden der organischen Chemie" [Methods of Organic Chemistry], 4th edition, vol. E XI/2, pp. 1067ff., Thieme Verlag Stuttgart, 1985; Houben-Weyl-Muller, "Methoden der organischen Chemie" [Methods of Organic Chemistry], 4th edition, vol. IX, pp. 563ff., Thieme Verlag Stuttgart, 1955; sulfonation by analogy with Houben-Weyl-Klamann, "Methoden der organischen Chemie" [Methods of Organic Chemistry], 4th edition, vol. E XI/2, pp. 1055ff., Thieme Verlag Stuttgart, 1985; Houben-Weyl-Muller, "Methoden der organischen Chemie" [Methods of Organic Chemistry], 4th edition, vol. IX, pp. 435ff., Thieme Verlag Stuttgart, 1955.

The (thio) isocyanates of the formula (V') are obtainable by methods known from the literature (EP-A-232 067, EP-A-166 516). The reaction of the (thio) isocyanates (V') with compounds (II) is carried out at from -10° C. to 100° C., preferably from 20° to 100° C., in an inert aprotic solvent such as acetone or acetonitrile in the presence of a suitable base, for example N(C₂ H₅)₃ or K₂ CO₃.

The salts of the compounds of the formula (I) are preferably prepared in inert polar solvents such as water, methanol or acetone at temperatures of 0°-100° C. Examples of bases which are suitable for the preparation of the salts according to the invention are alkali metal carbonates such as potassium carbonate, alkali metal hydroxides and alkali earth metal hydroxides, for example NaOH or KOH, or ammonia or ethanolamine.

The inert solvents referred to in the abovementioned process variants are in each case solvents which are inert under the respective reaction conditions, but which are not necessarily inert under any reaction conditions.

The compounds of the formula (I) according to the invention have an excellent herbicidal activity against a broad range of economically important monocotyledon and dicotyledon harmful plants. The active substances also act efficiently on perennial weeds which produce shoots from rhizomes, root stocks or other perennial organs and which are difficult to control. In this context, it does not matter whether the substances are applied before sowing, pre-emergence or post-emergence.

Specifically, examples may be mentioned of some representatives of the monocotyledon and dicotyledon weed flora which can be controlled by the compounds according to the invention, without the mention intending restriction to certain species.

Examples of weed species on which the active substance acts efficiently are, from amongst the monocotyledons, Avena, Lolium, Alopecurus, Phalaris, Echinochloa, Digitaria, Setaria and also Cyperus species from the annual sector and from amongst the perennial species Agropyron, Cynodon, Imperata and Sorghum, and also perennial Cyperus species.

In the case of the dicotyledon weed species, the range of action extends to species such as, for example, Galium, Viola, Veronica, Lamium, Stallaria, Amaranthus, Sinapis, Ipomoea, Matricaria, Abutilon and Sida from amongst the annuals, and Convolvulus, Cirsium, Rumex and Artemisia in the case of the perennial weeds.

The active substances according to the invention likewise effect outstanding control of weeds which occur under the specific conditions of rice-growing, such as, for example, Sagittaria, Alisma, Eleocharis, Scirpus and Cyperus.

If the compounds according to the invention are applied to the soil surface before germination, then the weed seedlings are either prevented completely from emerging, or the weeds grow until they have reached the cotyledon stage but then their growth stops and, eventually, after three to four weeks have elapsed, they die completely.

If the active substances are applied post-emergence on the green parts of the plants, growth likewise stops drastically a very short time after the treatment and the weed plants remain at the growth stage of the point in time of application, or they die completely after a certain time, so that in this manner competition by the weeds, which is harmful to the crop plants, is eliminated at a very early point in time and in a sustained manner.

Even though the compounds according to the invention have an excellent herbicidal activity against monocotyledon and dicotyledon weeds, crop plants of economically important crops, such as, for example, wheat, barley, rye, rice, maize, sugar beet, cotton and soya, are damaged not at all, or only to a negligible extent. For these reasons, the present compounds are highly suitable for selectively controlling unwanted plant growth in agricultural crop plants.

In addition, the substances according to the invention exhibit outstanding growth-regulatory properties in crop plants. They intervene to regulate the plant metabolism and can therefore be employed so as to have a specific influence on substances contained in plants, and for facilitating harvesting, for example by initiating desiccation and growth compression. Furthermore, they are also suitable for the general control and inhibition of unwanted vegetative growth, without killing off the plants in the process. Inhibition of vegetative growth plays an important role in many monocotyledon and dicotyledon crops, since it can reduce or completely prevent lodging.

The compounds according to the invention can be used in the form of wettable powders, emulsifiable concentrates, sprayable solutions, dusting agents or granules in the conventional formulations. The invention therefore also relates to herbicidal and plant growth-regulating compositions comprising compounds of the formula (I).

The compounds of the formula (I) can be formulated in a variety of ways, as predetermined by the biological and/or chemicophysical parameters. The following possibilities are therefore suitable for formulation: wettable powders (WP), water-soluble powders (SP), water-soluble concentrates, emulsifiable concentrates (EC), emulsions (EW) such as oil-in-water and water-in-oil emulsions, sprayable solutions, suspension concentrates (SC), dispersions on an oil or water base, oil-miscible solutions, capsule suspensions (CS), dusting agents (DP), seed-dressing agents, granules for scattering and soil application, granules (GR) in the form of microgranules, sprayable granules, coated granules and adsorption granules, water-dispersible granules (WG), water-soluble granules (SG), ULV formulations, microcapsules and waxes.

These individual formulation types are known in principle and are described, for example in: Winnacker-Kuchler, "Chemische Technologie" [Chemical Technology], Volume 7, C. Hauser Verlag Munich, 4th Ed., 1986; Wade van Valkenburg, "Pesticide Formulations", Marcel Dekker New York, 1973; K. Martens, "Spray Drying" Handbook, 3rd Ed. 1979, G. Goodwin Ltd. London.

The formulation auxiliaries required, such as inert materials, surfactants, solvents and other additives, are likewise known and are described, for example, in: Watkins, "Handbook of Insecticide Dust Diluents and Carriers", 2nd Ed., Darland Books, Caldwell N.J., H. v. Olphen, "Introduction to Clay Colloid Chemistry", 2nd Ed., J. Wiley & Sons, New York; C. Marsden, "Solvents Guide", 2nd Ed., Interscience, New York 1963; McCutcheon's "Detergents and Emulsifiers Annual", MC Publ. Corp., Ridgewood N.J.; Sisley and Wood, "Encyclopedia of Surface Active Agents", Chem. Publ. Co. Inc., New York 1964; Schonfeldt, "Grenzflachenaktive Athylenoxidaddukte" [Surface-active Ethylene Oxide Adducts], Wiss. Verlagsgesell., Stuttgart 1976; Winnacker-Kuchler, "Chemische Technologie" [Chemical Technology], Volume 7, C. Hauser Verlag Munich, 4th Ed. 1986.

Combinations with other pesticidally active substances, such as insecticides, acaricides, herbicides, fungicides, and with safeners, fertilizers and/or growth regulators may also be prepared on the basis of these formulations, for example in the form of a ready-to-use formulation or as a tank mix.

Wettable powders are preparations which are uniformly dispersible in water and which, besides the active substance, also contain surfactants of ionic and/or nonionic type (wetting agents, dispersants), for example polyethoxylated alkylphenols, polyethoxylated fatty alcohols, polyethoxylated fatty amines, fatty alcohol polyglycol ether sulfates, alkanesulfonates, alkylbenzenesulfonates, sodium ligninsulfonate, sodium 2,2'-dinaphthylmethane-6,6'-disulfonate, sodium dibutylnaphthalenesulfonate, or alternatively sodium oleoylmethyltaurinate, in addition to a diluent or inert substance. The wettable powders are prepared by finely grinding the herbicidal active substances, for example, in conventional apparatus such as hammer mills, blower mills and air-jet mills, and mixing them simultaneously or subsequently with the formulation auxiliaries.

Emulsifiable concentrates are prepared by dissolving the active substance in an organic solvent, for example butanol, cyclohexanone, dimethylformamide, xylene and also higher-boiling aromatic compounds or hydrocarbons or mixtures of the organic solvents, with the addition of one or more surfactants of ionic and/or nonionic type (emulsifiers). Examples of emulsifiers which can be used are: calcium salts of an alkylarylsulfonic acid such as Ca dodecylbenzenesulfonate, or nonionic emulsifiers, such as fatty acid polyglycol esters, alkylaryl polyglycol ethers, fatty alcohol polyglycol ethers, propylene oxide/ethylene oxide condensation products, alkyl polyethers, sorbitan esters, such as sorbitan fatty acid esters or polyoxyethylene sorbitan esters, such as polyoxyethylene sorbitan fatty esters.

Dusting agents are obtained by grinding the active substance with finely divided solid substances, for example talc or natural clays, such as kaolin, bentonite, pyrophyllite or diatomaceous earth.

Suspension concentrates may be based on water or oil. They can be prepared by, for example, wet grinding using conventional bead mills with the possible addition of surfactants as already mentioned, for example, above for the other types of formulation.

Emulsions, for example oil-in-water emulsions (EW), can be prepared, for example, by means of stirrers, colloid mills and/or static mixers, using aqueous organic solvents and, if desired, surfactants, for example as already listed above for the other types of formulation.

Granules can be produced either by spraying the active substance onto adsorptive, granulated inert material or by applying active substance concentrates onto the surface of carriers, such as sand, kaolinites or granulated inert material, by means of binders, for example polyvinyl alcohol, sodium polyacrylate or, alternatively, mineral oils. Suitable active substances can also be granulated in the manner which is conventional for the production of fertilizer granules, if desired in a mixture with fertilizers.

Water-dispersible granules are generally prepared by conventional methods such as spray-drying, fluidized-bed granulation, plate granulation, mixing using high-speed mixers and extrusion without solid inert material. For the preparation of plate, fluidized-bed, extrusion and spray granules, see for example processes in "Spray-Drying Handbook" 3rd edition, 1979, G. Goodwin Ltd., London; J. E. Browning, "Agglomeration", Chemical and Engineering 1967, pages 147 ff; "Perry's Chemical Engineer's Handbook", 5th edition, McGraw-Hill, New York 1973, pp. 8-57.

For further details on the formulation of crop protection compositions see, for example, G. C. Klingman, "Weed Control as a Science", John Wiley and Sons Inc., New York, 1961, pp. 81-96 and J. D. Freyer, S. A. Evans, "Weed Control Handbook", 5th edition, Blackwell Scientific Publications, Oxford, 1968, pp. 101-103.

The agrochemical formulations generally contain from 0.1 to 99% by weight and in particular from 0.1 to 95% by weight of active substance of the formula (I). The concentration of active substance in wettable powders is, for example, about 10 to 90% by weight; the remainder to 100% by weight is composed of conventional formulation components. In the case of emulsifiable concentrates, the concentration of active substance can be about 1 to 90, preferably 5 to 80% by weight. Formulations in the form of dusts contain 1 to 30, usually preferably 5 to 20% by weight of active substance, sprayable solutions about 0.05 to 80, preferably 2 to 50% by weight. In the case of water-dispersible granules, the active substance content depends partly on whether the active compound is liquid or solid and on which granulation auxiliaries, fillers etc. are used. In the case of the water-dispersible granules, the content of active substance is, for example, between 1 and 95% by weight and preferably between 10 and 80% by weight.

In addition, the active substance formulations mentioned contain, if appropriate, the adhesives, wetting agents, dispersants, emulsifiers, penetrants, preservatives, frost protectors and solvents, fillers, carriers and colorants, antifoams, evaporation inhibitors and agents influencing the pH and the viscosity which are conventional in each case.

Combination partners which can be employed for the active substances according to the invention in mixed formulations or as a tank mix are, for example, known active substances as described in, for example, Weed Research 26, 441-445 (1986), or "The Pesticide Manual", 9th edition, The British Crop Protection Council, 1990/91, Bracknell, England, and the literature quoted therein. Examples of herbicides known from the literature which can be combined with the compounds of the formula (I) are the following active substances (note: the compounds are either given by their common name in accordance with the International Organization for Standardization (ISO) or by the chemical name, together if appropriate with a common code number): acetochlor; acifluorfen; aclonifen; AKH 7088, i.e. [[[1-[5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrophenyl]-2-methoxyethylidene]amino]oxy]acetic acid and its methyl ester; alachlor; alloxydim; ametryn; amidosulfuron; amitrol; AMS, i.e. ammonium sulfamate; anilofos; asulam; atrazin; azimsulfurone (DPX-A8947); aziprotryn; barban; BAS 516 H, i.e. 5-fluoro-2-phenyl-4H-3,1-benzoxazin-4-one; benazolin; benfluralin; benfuresate; bensulfuron-methyl; bensulide; bentazone; benzolenap; benzofluor; benzoylprop-ethyl; benzthiazuron; bialaphos; bifenox; bromacil; bromobutide; bromofenoxim; bromoxynil; bromuron; buminafos; busoxinone; butachlor; butamifos; butenachlor; buthidazole; butralin; butylate; cafenstrole (CH-900); carbetamide; cafentrazone (ICI-A0051); CDAA, i.e. 2-chloro-N,N-di-2-propenylacetamide; CDEC, i.e. 2-chloroallyl diethyldithiocarbamate;, chlomethoxyfen; chloramben; chlorazifop-butyl, chlormesulon (ICI-A0051); chlorbromuron; chlorbufam; chlorfenac; chlorflurecolmethyl; chloridazon; chlorimuron ethyl; chlornitrofen; chlorotoluron; chloroxuron; chlorpropham; chlorsulfuron; chlorthal-dimethyl; chlorthiamid; cinmethylin; cinosulfuron; clethodim; clodinafop and its ester derivatives (for example clodinafop-propargyl); clomazone; clomeprop; cloproxydim; clopyralid; cumyluron (JC 940); cyanazine; cycloate; cyclosulfamuron (AC 104); cycloxydim; cycluron; cyhalofop and its ester derivatives (for example butyl ester, DEH-112); cyperquat; cyprazine; cyprazole; daimuron; 2,4-DB; dalapon; desmedipham; desmetryn; di-allate; dicamba; dichlobenil; dichlorprop; diclofop and its esters such as diclofop-methyl; diethatyl; difenoxuron; difenzoquat; diflufenican; dimefuron; dimethachlor; dimethametryn; dimethenamide (SAN-582H); dimethazone, clomazon; dimethipin; dimetrasulfuron, dinitramine; dinoseb; dinoterb; diphenamid; dipropetryn; diquat; dithiopyr; diuron; DNOC; eglinazine-ethyl; EL 177, i.e. 5-cyano-1-(1,1-dimethylethyl)-N-methyl-1H-pyrazole-4-carboxamide; endothal; EPTC; esprocarb; ethalfluralin; ethametsulfuron-methyl; ethidimuron; ethiozin; ethofumesate; F5231, i.e. N-[2-chloro-4-fluoro-5-[4-(3-fluoropropyl)-4,5-dihydro-5-oxo-1H-tetrazol-1-yl]phenyl]ethanesulfonamide; ethoxyfen and its esters (e.g. ethyl ester, HN-252); etobenzanid (HW 52); fenoprop; fenoxan, fenoxaprop and fenoxaprop-P and esters thereof, e.g. fenoxaprop-P-ethyl and fenoxaprop-ethyl; fenoxydim; fenuron; flamprop-methyl; flazasulfuron; fluazifop end fluazifop-P and esters thereof, e.g. fluazifop-butyl and fluazifop-P-butyl; fluchloralin; flumetsulam; flumeturon; flumiclorac and its esters (e.g. pentyl ester, S-23031); flumioxazin (S-482); flumipropyn; flupoxam (KNW-739); fluorodifen; fluoroglycofen-ethyl; flupropacil (UBIC-4243); fluridone; flurochloridone; fluroxypyr; flurtamone; fomesafen; fosamine; furyloxyfen; glufosinate; glyphosate; halosaten; halosulfuron and its esters (e.g. methyl esters, NC-319); haloxyfop and its esters; haloxyfop-P (═R-haloxyfop) and its esters; hexazinone, imazamethabenz-methyl; imazapyr; imazaquin and salts such as the ammonium salt; imazethamethapyr; imazethapyr; imazosulfuron; ioxynil; isocarbamid; isopropalin; isoproturon; isouron; isoxaben; isoxapyrifop; karbutilate; lactofen; lenacil; linuron; MCPA; MCPB; mecoprop; mefenacet; mefluidid; metamitron; metazachlor; methabenzthiazuron; metham; methazole; methoxyphenone; methyldymron; metabenzuron; methobenzuron; metobromuron; metolachlor; metosulam (XRD511); metoxuron; metribuzin; metsulfuron-methyl; MH; molinate; monalide; monocarbamide dihydrogensulfate; monolinuron; monuron; MT 128, i.e. 6-chloro-N-(3-chloro-2-propenyl)-5-methyl-N-phenyl-3-pyridazinamin; MT 5950, i.e. N-[3-chloro-4-(1-methylethyl)-phenyl]-2-methylpentanamide; naproanilide; napropamide; naptalam; NC 310, i.e. 4-(2,4-dichlorobenzoyl)-1-methyl-5-benzyloxypyrazole; neburon; nicosulfuron; nipyraclophen; nitralin; nitrofen; nitrofluorfen; norflurazon; orbencarb; oryzalin; oxadiargyl (RP-020630); oxadiazon; oxyfluorfen; paraquat; pebulate; pendimethalin; perfluidone; phenisopham; phenmedipham; picloram; piperophos; piributicarb; pirifenop-butyl; pretilachlor; primisulfuron-methyl; procyazine; prodiamine; profluralin; proglinazine-ethyl; prometon; prometryn; propachlor; propanil; propaquizafop and its esters; propazine; propham; propisochlor; propyzamide; prosulfalin; prosulfocarb; prosulfuron (CGA-152005); prynachlor; pyrazolinate; pyrazon; pyrazosulfuron-ethyl; pyrazoxyfen; pyridate; pyrithiobac (KIH-2031); pyroxofop and its esters (e.g. propargyl ester); quinclorac; quinmerac; quinofop and its ester derivatives, quizalofop and quizalofop-P and their ester derivatives, e.g. quizalofop-ethyl; quizalofop-P-tefuryl and -ethyl; renriduron; rimsulfuron (DPX-E 9636); S 275, i.e. 2-[4-chloro-2-fluoro-5-(2-propynyloxy)-phenyl]-4,5,6,7-tetrahydro-2H-indazole; secbumeton; sethoxydim; siduron; simazine; simetryn; SN 106279, i.e. 2-[[7-[2-chloro-4-(trifluoro-methyl)-phenoxy]-2-naphthalenyl]-oxy]propanoic acid and its methyl ester; sulfentrazon (FMC-97385, F-6285); sulfazuron; sulfometuron-methyl; sulfosate (ICI-A0224); TCA; tebutam (GCP-5544); tebuthiuron; terbacil; terbucarb; terbuchlor; terbumeton; terbuthylazine; terbutryn; TFH 450, i.e. N,N-diethyl-3-[(2-ethyl-6-methylphenyl)-sulfonyl]-1H-1,2,4-triazol-1-carboxamide; thenylchlor (NSK-850); thiazafluron; thizopyr (Mon-13200); thidiazimin (SN-124085); thifensulfuron-methyl; thiobencarb; tiocarbazil; tralkoxydim; tri-allate; triasulfuron; triazofenamide; tribenuron-methyl; triclopyr; tridiphane; trietazine; trifluralin; triflusulfuron and esters (e.g. methyl ester, DPX-66037); trimeturon; tsitodef; vernolate; WL 110547, i.e. 5-phenoxy-1-[3-(trifluoromethyl)-phenyl]-1H-tetrazole; UBH-509; D-489; LS 82-556; KPP-300; NC-324; NC-330; KH-218; DPX-N8189; SC-0774; DOWCO-535; DK-8910; V-53482; PP-600; MBH-001; KIH-9201; ET-751; KIH-6127 and KIH-2023.

For use, the formulations, present in commercially available form, are diluted, if appropriate, in a customary manner, for example using water in the case of wettable powders, emulsifiable concentrates, dispersions and water-dispersible granules. Preparations in the form of dusts or granules for soil application and scattering, and also sprayable solutions, are usually not further diluted with other inert substances before use.

The application rate required for the compounds of the formula I varies with the external conditions, such as, inter alia, temperature, humidity, and the nature of the herbicide used. It can vary within wide limits, for example between 0.001 and 10.0 kg/ha or more of active substance; preferably, however, it is between 0.005 and 5 kg/ha.

A. Chemical Examples

Abbreviations: The percentages and proportions relate to weight unless specified more closely.

i.v.=under reduced pressure

h=hour(s)

EXAMPLE A1

N-tert-Butyl-5-bromomethyl-2-methoxycarbonylbenzenesulfonamide

A solution of 54.8 g (192 mmol) of N-tert-butyl-2-methoxycarbonyl-5-methylbenzenesulfonamide in 420 ml of tetrachloromethane is heated at reflux for 6-8 h under a nitrogen protective-gas atmosphere, following addition of 36 g (202 mmol) of N-bromosuccinimide and 0.5 g of azobisisobutyronitrile (AIBN) with simultaneous irradiation with a daylight lamp. The solution is then filtered and then washed in succession with sodium disulphide solution, sodium hydrogen carbonate solution and water, dried over Na₂ SO₄ and evaporated to dryness i.v. Crystallization of the residue from diisopropyl ether/ethyl acetate yields 41.9 g (57%) of N-tert-butyl-5-bromomethyl-2-methoxycarbonylbenzenesulfonamide of mp. 88°-90° C.

EXAMPLE A2

N-tert-Butyl-5-azidomethyl-2-methoxycarbonylbenzenesulfonamide

A solution of 25.5 g (70 mmol) of N-tert-butyl-5-bromomethyl-2-methoxycarbonylbenzenesulfonamide and 5.9 g (90 mmol) of sodium azide in 240 ml of ethanol is heated at reflux for 6 h. The solution is then evaporated to dryness and the residue is extracted with water/ethyl acetate. Digestion of the crude product with diisopropyl ether gives 16.6 g (72.5%) of N-tert-butyl-5-azidomethyl-2-methoxycarbonylbenzenesulfonamide of mp. 63°-65° C.

EXAMPLE A3

N-tert-Butyl-5-aminomethyl-2-methoxycarbonylbenzenesulfonamide

16.3 g (50 mmol) of N-tert-butyl-5-azidomethyl-2-methoxycarbonylbenzenesulfonamide are dissolved in 300 ml of methanol and hydrogenated over Pd/C (5%). The mixture is filtered and evaporated to dryness. The crude product obtained is purified by elution through a silica gel column using ethyl acetate/methanol 4:1.11.2 g (74%) of N-tert-butyl-5-aminomethyl-2-methoxycarbonylbenzenesulfonamide are obtained as a viscous oil.

¹ H NMR (100 MHz, CDCl₃): δ=1.25 (s, 9H, C(CH₃)₃), 1.80 (bs, 2H, NH₂), 3.95 (s, 3H, OCH₃), 4.00 (s, 2H, Ar--CH₂), 6.20 (bs, 1H, SO₂ NH), 7.58 (dd, 1H, Ar--H), 7.80 (d, 1H, Ar--H), 8.10 (dd, 1H, Ar--H).

EXAMPLE A4

N-tert-Butyl-5-acetamidomethyl-2-methoxycarbonylbenzenesulfonamide

0.63 g (8 mmol) of acetyl chloride dissolved in 10 ml of dichloromethane is added dropwise to a solution, cooled to 0° C., of 2.01 g (6.7 mmol) of N-tert-butyl-5-aminomethyl-2-methoxycarbonylbenzenesulfonamide and 0.93 ml (6.7 mmol) of triethylamine in 30 ml of dichloromethane, and the mixture is then stirred at room temperature for 2 h. The reaction solution is washed with water, dried and evaporated to dryness i.v. 2.1 g (91%) of N-tertbutyl-5-acetamidomethyl-2-methoxycarbonylbenzenesulfonamide are obtained as a viscous oil.

¹ H NMR (100 MHz, CDCl₃): δ=1.25 (s, 9H, C(CH₃)₃), 2.05 (s, 3H, COCH₃), 3.95 (s, 3H, OCH₃), 4.50 (s, 2H, Ar--CH₂), 6.15 (s, 1H, SO₂ NH), 6.38 (bt, 1H, NH), 7.47 (dd, 1H, Ar--H), 7.75 (d, 1H, Ar--H), 7.95 (dd, 1H, Ar--H).

EXAMPLE A5

5-Acetamidomethyl-2-methoxycarbonylbenzenesulfonamide

A solution of 2.09 g (6.1 mmol) of N-tert-butyl-5-acetamidomethyl-2-methoxycarbonylbenzenesulfonamide in 25 ml of trifluoroacetic acid is stirred at room temperature for 14 h and then evaporated to dryness. Crystallization of the residue from ethyl acetate yields 1.33 g (76%) of 5-acetamidomethyl-2-methoxycarbonylbenzenesulfonamide of mp. 173°-175° C.

EXAMPLE A6

N-[4,6-Dimethoxypyrimidin-2-yl)aminocarbonyl]-5-acetamidomethyl-2-methoxycarbonylbenzenesulfonamide

0.69 g (4.54 mmol) of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) is added at 0° C. to a suspension of 1.3 g (4.54 mmol) of 5-acetamidomethyl-2-methoxycarbonylbenzenesulfonamide and 1.25 g (4.54 mmol) of N-4,6-dimethoxypyrimidin-2-yl)phenylcarbamate in 20 ml of acetonitrile. After 2 h at room temperature, the mixture is diluted with water and diethyl ether, acidified to pH 1-2 with hydrochloric acid, and the resulting precipitate is filtered off and dried. 1.32 g (62%) of N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-5-acetamidomethyl-2-methoxycarbonylbenzenesulfonamide of mp. 149°-150° C. are obtained.

The compounds of the formula (I) listed in the following tables 1-4 (W═O, A=pyrimidinyl or triazinyl) are obtained in analogy to Examples A1 to A6. In the tables:

Mp.=melting point in °C.

CN=compound number=example number

Me=methyl=CH₃

Et=ethyl

Bu=n-Bu=n-butyl=n-C₄ H₉

Ph=phenyl

                                      TABLE 1                                      __________________________________________________________________________      ##STR18##                                                                     CN  R.sup.1                                                                               R.sup.4   R.sup.5      R.sup.7                                                                            X      Y       Z   Mp.                   __________________________________________________________________________                                                              °C.            1   CO.sub.2 CH.sub.3                                                                     H         CHO          H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  124-125               2   "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        3   "      "         "            H   CH.sub.3                                                                              CH.sub.3                                                                               CH                        4   "      "         "            H   CH.sub.3                                                                              OC.sub.2 H.sub.5                                                                       CH                        5   "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         6   "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         7   "      "         "            H   OCH.sub.3                                                                             Cl      CH                        8   "      "         "            H   OCF.sub.2 H                                                                           CH.sub.3                                                                               CH                        9   "      "         "            H   OCF.sub.2 H                                                                           OCF.sub.2 H                                                                            CH                        10  "      "         "            H   OCH.sub.3                                                                             Br      CH                        11  "      "         "            H   OCH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       CH                        12  "      "         "            H   OCH.sub.3                                                                             SCH.sub.3                                                                              CH                        13  "      "         "            H   OCH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       N                         14  "      "         "            H   OCH.sub.3                                                                             OC.sub.3 H.sub.7                                                                       CH                        15  "      "         "            H   CH.sub.3                                                                              Cl      CH                        16  "      "         "            H   CL     OC.sub.2 H.sub.5                                                                       CH                        17  "      "         "            H   OC.sub.2 H.sub.5                                                                      OC.sub.2 H.sub.5                                                                       CH                        18  "      "         "            H   C.sub.2 H.sub.5                                                                       OCH.sub.3                                                                              CH                        19  "      "         "            H   CF.sub.3                                                                              OCH.sub.3                                                                              CH                        20  "      "         "            H   OCH.sub.2 CF.sub.3                                                                    CH.sub.3                                                                               CH                        21  "      "         "            H   OCH.sub.2 CF.sub.3                                                                    OCH.sub.3                                                                              CH                        22  "      "         "            H   OCH.sub.2 CF.sub.3                                                                    OCH.sub.2 CF.sub.3                                                                     CH                        23  "      "         "            H   OCH.sub.2 CF.sub.3                                                                    OCH.sub.3                                                                              N                         24  "      "         "            H   OCH.sub.3                                                                             CH(OCH.sub.3).sub.2                                                                    CH                        25  "      "         "            CH.sub.3                                                                           OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        26  "      "         "            CH.sub.3                                                                           OCH.sub.3                                                                             CH.sub.3                                                                               N                         27  "      H         COCH.sub.3   H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  149-150               28  "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        29  "      "         "            H   CH.sub.3                                                                              CH.sub.3                                                                               CH                        30  "      "         "            H   CH.sub.3                                                                              OC.sub.2 H.sub.5                                                                       CH                        31  "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         32  "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         33  "      "         "            H   OCH.sub.3                                                                             Cl      CH                        34  "      "         "            H   OCF.sub.2 H                                                                           CH.sub.3                                                                               CH                        35  "      "         "            H   OCF.sub.2 H                                                                           OCF.sub.2 H                                                                            CH                        36  "      "         "            H   OCH.sub.3                                                                             Br      CH                        37  "      "         "            H   OCH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       CH                        38  "      "         "            H   OCH.sub.3                                                                             SCH.sub.3                                                                              CH                        39  "      "         "            H   OCH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       N                         40  "      "         "            H   OCH.sub.3                                                                             OC.sub.3 H.sub.7                                                                       CH                        41  "      "         "            H   CH.sub.3                                                                              Cl      CH                        42  "      "         "            H   Cl     OC.sub.2 H.sub.5                                                                       CH                        43  "      "         "            H   OC.sub.2 H.sub..sub.5                                                                 OC.sub.2 H.sub.5                                                                       CH                        44  "      "         "            H   C.sub.2 H.sub.5                                                                       OCH.sub.3                                                                              CH                        45  "      "         "            H   CF.sub.3                                                                              OCH.sub.3                                                                              CH                        46  "      "         "            H   OCH.sub.2 CF.sub.3                                                                    CH.sub.3                                                                               CH                        47  "      "         "            H   OCH.sub.2 CF.sub.3                                                                    OCH.sub.3                                                                              CH                        48  "      "         "            H   OCH.sub.2 CF.sub.3                                                                    OCH.sub.2 CF.sub.3                                                                     CH                        49  "      "         "            H   OCH.sub.2 CF.sub.3                                                                    OCH.sub.3                                                                              N                         50  "      "         "            H   OCH.sub.3                                                                             CH(OCH.sub.3).sub.2                                                                    CH                        51  "      "         "            CH.sub.3                                                                           OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        52  "      "         "            CH.sub.3                                                                           OCH.sub.3                                                                             CH.sub.3                                                                               N                         53  "      CH.sub.3  CHO          H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  171-175               54  "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH  135-140               55  "      "         "            H   CH.sub.3                                                                              CH.sub.3                                                                               CH  123-126               56  "      "         "            H   CH.sub.3                                                                              OC.sub.2 H.sub.5                                                                       CH                        57  "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         58  "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N   105                   59  "      "         "            H   OCH.sub.3                                                                             Cl      CH  125-130               60  "      "         "            H   OCF.sub.2 H                                                                           CH.sub.3                                                                               CH                        61  "      "         "            H   OCF.sub.2 H                                                                           OCF.sub.2 H                                                                            CH                        62  "      "         "            H   OCH.sub.3                                                                             Br      CH                        63  "      "         "            H   OCH.sub.3                                                                             OCF.sub.2 H.sub.5                                                                      CH                        64  "      "         "            H   OCH.sub.3                                                                             SCH.sub.3                                                                              CH                        65  "      "         "            H   OCH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       N                         66  "      "         "            H   OCH.sub.3                                                                             OC.sub.3 H.sub.7                                                                       CH                        67  "      "         "            H   CH.sub.3                                                                              Cl      CH                        68  "      "         "            H   Cl     OC.sub.2 H.sub.5                                                                       CH                        69  "      "         "            H   OC.sub.2 H.sub.5                                                                      OC.sub.2 H.sub.5                                                                       CH                        70  "      "         "            H   C.sub.2 H.sub.5                                                                       OCH.sub.3                                                                              CH                        71  "      "         "            H   CF.sub.3                                                                              OCH.sub.3                                                                              CH                        72  "      "         "            H   OCH.sub.2 CF.sub.3                                                                    CH.sub.3                                                                               CH                        73  "      "         "            H   OCH.sub.2 CF.sub.3                                                                    OCH.sub.3                                                                              CH                        74  "      "         "            H   OCH.sub.2 CF.sub.3                                                                    OCH.sub.2 CF.sub.3                                                                     CH                        75  "      "         "            H   OCH.sub.2 CF.sub.3                                                                    OCH.sub.3                                                                              N                         76  "      "         "            H   OCH.sub.3                                                                             CH(OCH.sub.3).sub.2                                                                    CH                        77  "      "         "            CH.sub.3                                                                           OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        78  "      "         "            CH.sub.3                                                                           OCH.sub.3                                                                             CH.sub.3                                                                               N                         79  "      CH.sub.3  COCH.sub.3   H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  146-149               80  "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        81  "      "         "            H   CH.sub.3                                                                              CH.sub.3                                                                               CH                        82  "      "         "            H   CH.sub.3                                                                              OC.sub.2 H.sub.5                                                                       CH                        83  "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         84  "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         85  "      "         "            H   OCH.sub.3                                                                             Cl      CH                        86  "      "         "            H   OCF.sub.2 H                                                                           CH.sub.3                                                                               CH                        87  "      "         "            H   OCF.sub.2 H                                                                           OCF.sub.2 H                                                                            CH                        88  "      "         "            H   OCH.sub.3                                                                             Br      CH                        89  "      "         "            H   OCH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       CH                        90  "      "         "            H   OCH.sub.3                                                                             SCH.sub.3                                                                              CH                        91  "      "         "            H   OCH.sub.3                                                                             Oc.sub.2 H.sub.5                                                                       N                         92  "      "         "            H   OCH.sub.3                                                                             OC.sub.3 H.sub.7                                                                       CH                        93  "      "         "            H   CH.sub.3                                                                              Cl      CH                        94  "      "         "            H   Cl     OC.sub.2 H.sub.5                                                                       CH                        95  "      "         "            H   OC.sub.2 H.sub.5                                                                      OC.sub.2 H.sub.5                                                                       CH                        96  "      "         "            H   C.sub.2 H.sub.5                                                                       OCH.sub.3                                                                              CH                        97  "      "         "            H   CF.sub.3                                                                              OCH.sub.3                                                                              CH                        98  "      "         "            H   OCH.sub.2 CF.sub.3                                                                    CH.sub.3                                                                               CH                        99  "      "         "            H   OCH.sub.2 CF.sub.3                                                                    OCH.sub.3                                                                              CH                        100 "      "         "            H   OCH.sub.2 CF.sub.3                                                                    OCH.sub.2 CF.sub.3                                                                     CH                        101 "      "         "            H   OCH.sub.2 CF.sub.3                                                                    OCH.sub.3                                                                              N                         102 "      "         "            H   OCH.sub.3                                                                             CH(OCH.sub.3).sub.2                                                                    CH                        103 "      "         "            CH.sub.3                                                                           OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        104 "      "         "            CH.sub.3                                                                           OCH.sub.3                                                                             CH.sub.3                                                                               N                         105 "      H         SO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  192-194               106 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        107 "      "         "            H   CH.sub.3                                                                              CH.sub.3                                                                               CH                        108 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         109 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         110 "      "         "            H   OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                         111 "      "         "            CH.sub.3                                                                           OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        112 "      "         "            CH.sub.3                                                                           OCH.sub.3                                                                             CH.sub.3                                                                               N                         113 "      CH.sub.3  SO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  107-109               114 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        115 "      "         "            H   CH.sub.3                                                                              CH.sub.3                                                                               CH                        116 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         117 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         118 "      "         "            H   OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                         119 "      "         "            CH.sub.3                                                                           OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        120 "      "         "            CH.sub.3                                                                           OCH.sub.3                                                                             CH.sub.3                                                                               N                         121 "      OH        CHO          H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        122 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        123 "      "         "            H   CH.sub.3                                                                              CH.sub.3                                                                               CH                        124 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         125 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         126 "      "         "            H   OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                         127 "      "         "            CH.sub.3                                                                           OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        128 "      "         "            CH.sub.3                                                                           OCH.sub.3                                                                             CH.sub.3                                                                               N                         129 "      OCH.sub.3 CHO          H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  142-145               130 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        131 "      "         "            H   CH.sub.3                                                                              CH.sub.3                                                                               CH                        132 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         133 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         134 "      "         "            H   OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                         135 "      "         "            CH.sub.3                                                                           OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        136 "      "         "            CH.sub.3                                                                           OCH.sub.3                                                                             CH.sub.3                                                                               N                         137 "      OH        COCH.sub.3   H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        138 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        139 "      "         "            H   CH.sub.3                                                                              CH.sub.3                                                                               CH                        140 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         141 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         142 "      "         "            H   OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                         143 "      "         "            CH.sub.3                                                                           OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        144 "      "         "            CH.sub.3                                                                           OCH.sub.3                                                                             CH.sub.3                                                                               N                         145 "      OCH.sub.3 COCH.sub.3   H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  195-196               146 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        147 "      "         "            H   CH.sub.3                                                                              CH.sub.3                                                                               CH                        148 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         149 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         150 "      "         "            H   OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                         151 "      "         "            CH.sub.3                                                                           OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        152 "      "         "            CH.sub.3                                                                           OCH.sub.3                                                                             CH.sub.3                                                                               N                         153 "      H         COC.sub.2 H.sub.5                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  150-152               154 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        155 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         156 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         157 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        158 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        159 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         160 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         161 "      H         COCH.sub.2 OCH.sub.3                                                                        H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        162 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        163 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         164 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         165 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        166 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        167 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         168 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         169 "      H         COCO.sub.2 C.sub.2 H.sub.5                                                                  H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        170 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        171 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         172 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         173 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        174 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        175 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         176 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         177 "      H         COCF.sub.3   H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  158                   178 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        179 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         180 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         181 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  144-147               182 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        183 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         184 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         185 "      H         COOCH.sub.3  H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  160-161               186 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        187 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         188 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         189 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  157-159               190 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        191 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         192 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         193 "      H         CONHC.sub.2 H.sub.5                                                                         H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        194 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        195 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         196 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         197 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        198 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        199 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         200 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         201 "      H         CSNHC.sub.2 H.sub.5                                                                         H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        202 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        203 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         204 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         205 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        206 "      "         "            H   OCH.sub.2                                                                             CH.sub.3                                                                               CH                        207 "      "         "            N   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         208 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         209 "      H         SO.sub.2 NHCH.sub.3                                                                         H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        210 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        211 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         212 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         213 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  171-173               214 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        215 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         216 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         217 "      H         SO.sub.2 N(CH.sub.3).sub.2                                                                  H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  162                   218 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        219 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         220 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         221 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  127-129               222 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        223 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         224 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         225 "      CH.sub.2 CH.sub.2 CH.sub.2 CO                                                                         H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        226 "      "                      H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        227 "      "                      H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         228 "      "                      H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         229 "      CH.sub.2 CH.sub.2 CH.sub.2 SO.sub.2                                                                   H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        230 "      "                      H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        231 "      "                      H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         232 "      "                      H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         233 "      CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CO                                                                H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        234 "      "                      H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        235 "      "                      H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         236 "      "                      H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         237 "      CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 SO.sub.2                                                          H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        238 "      "                      H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        239 "      "                      H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         240 "      "                      H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         241 "      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                                                  H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        242 "      "                      H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        243 "      "                      H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         244 "      "                      H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         245 "      H         COC.sub.3 H.sub.7                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        246 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        247 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         248 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         249 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        250 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        251 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         252 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         253 "      H         COCH.sub.2 Cl                                                                               H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  144-145               254 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        255 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         256 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         257 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  138-140               258 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        259 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         260 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         261 "      H         COCHCl.sub.2 H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        262 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        263 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         264 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         265 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        266 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        267 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         268 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         269 "      H         COCCl.sub.3  H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        270 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        271 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         272 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         273 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        274 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        275 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         276 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         277 "      H         COCHCH.sub.2 H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        278 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        279 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         280 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         281 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        282 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        283 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         284 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         285 "      H         COCCH        H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        286 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        287 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         288 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         289 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        290 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        291 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         292 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         293 "      H         COC.sub.6 H.sub.5                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        294 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        295 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         296 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         297 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        298 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        299 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         300 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         301 "      SO.sub.2 C.sub.6 H.sub.5                                                                 SO.sub.2 C.sub.6 H.sub.5                                                                    H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        302 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        303 "      "         "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         339 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        340 "      "         "            H   OCH.sub.2                                                                             CH.sub.3                                                                               N                         341 "      H         COCH(CH.sub.3).sub.2                                                                        H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        342 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         343 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        344 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         345 "      H         COC(CH.sub.3).sub.3                                                                         H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        346 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         347 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        348 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         349 "      H         CO-Cyclopropyl                                                                              H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        350 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         351 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        352 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         353 "      H         CO-Cyclobutyl                                                                               H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        354 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         355 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        356 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         357 "      H         CO-Cyclopentyl                                                                              H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        358 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         359 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        360 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               H                         361 "      H         CO-Cyclohexyl                                                                               H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        362 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         363 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        364 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         365 "      H         CONHCH.sub.2 CH.sub.2 Cl                                                                    H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        366 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         367 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        368 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         369 "      H         CSNHCH.sub.2 CH.sub.2 Cl                                                                    H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        370 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         371 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        372 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         373 "      H         CONH-n-C.sub.4 H.sub.9                                                                      H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        374 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         375 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        376 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         377 "      H         CSNHCH.sub.3 H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        378 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         379 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        380 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         381 "      H         CSNHCH.sub.2 CHCH.sub.2                                                                     H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        382 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         383 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        384 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         385 "      CH.sub.3  CSNHCH.sub.2 COCH.sub.3                                                                     H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        386 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         387 "      CH.sub.3  CSNHCH.sub.2 COC.sub.2 H.sub.5                                                              H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        388 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         389 "      CH.sub.3  CONHCH.sub.2 COCH.sub.3                                                                     H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        390 "      "         "            OCH.sub.3                                                                          CH.sub.3                                                                              N                                 391 "      CH.sub.3  CONHCH.sub.2 COC.sub.2 H.sub.5                                                              H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        392 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         393 "      CONHCH.sub.2 CO        H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        394 "      "                      H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         395 "      H         SO.sub.2 CH.sub.2 F                                                                         H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        396 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         397 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        398 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         399 "      H         SO.sub.2 CF.sub.3                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        400 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         401 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        402 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         403 "      H         SO.sub.2 C.sub.2 H.sub.5                                                                    H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        404 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         405 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        406 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         407 "      H         SO.sub.2 -n-C.sub.3 H.sub.7                                                                 H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        408 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         409 "      CH.sub.3  "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        410 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         411 "      OH        COC.sub.2 H.sub.5                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        412 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         413 "      OCH.sub.3 "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        414 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         415 "      OH        COCH.sub.2 Cl                                                                               H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        416 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         417 "      OCH.sub.3 "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        418 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         419 "      OH        COCF.sub.3   H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        420 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         421 "      OCH.sub.3 "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  159-161               422 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         423 "      OH        COCH.sub.2 OCH.sub.3                                                                        H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        424 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         425 "      OCH.sub.3 "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  130-131               426 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         427 "      OH        COCO.sub.2 C.sub.2 H.sub.5                                                                  H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        428 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         429 "      OCH.sub.3 "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  158-159               430 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         431 "      OH        COOCH.sub.3  H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        432 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         433 "      OCH.sub.3 "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  137-138               434 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         435 "      OH        Cyclopropyl  H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        436 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         437 "      OCH.sub.3 "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  118-120               438 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         439 "      OH        COC.sub.6 H.sub.5                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        440 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         441 "      OCH.sub.3 "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        442 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         443 "      OH        COCH(CH.sub.3).sub.2                                                                        H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        444 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         445 "      OCH.sub.3 "            H   OCH.sub.2                                                                             OCH.sub.3                                                                              CH  126-128               446 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         447 "      OH        COCHCH.sub.2 H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        448 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         449 "      OCH.sub.3 "            H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        450 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         451 "      OH        COCCH        H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        452 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         453 "      OCH.sub.3 "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        454 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         455 "      OH        SO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        456 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         457 "      OCH.sub.3 "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  146-148               458 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         459 "      OH        SO.sub.2 NHCH.sub.3                                                                         H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        460 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         461 "      OCH.sub.3 "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  179-180               462 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         463 "      OH        SO.sub.2 N(CH.sub.3).sub.2                                                                  H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        464 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         465 "      OCH.sub.3 "            H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  179-180               466 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         467 "      C.sub.2 H.sub.5                                                                          CHO          H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  168-170               468 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         469 "      "         COCH.sub.3   H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        470 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         471 "      "         Clyclopropyl H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        472 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         473 "      "         COCH.sub.2 Cl                                                                               H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        474 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         475 "      "         COCF.sub.3   H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        476 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         477 "      "         COOCH.sub.3  H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        478 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         479 "      "         COC.sub.6 H.sub.5                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        480 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         481 "      "         CONHC.sub.2 H.sub.5                                                                         H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        482 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         483 "      "         CSNHC.sub.2 H.sub.5                                                                         H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        484 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         485 "      "         SO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  154-155               486 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         487 "      "         SO.sub.2 NHCH.sub.3                                                                         H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  150-152               488 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         489 "      "         SO.sub.2 N(CH.sub.3).sub.2                                                                  H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        490 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         491 "      "         SO.sub.2 C.sub.6 H.sub.5                                                                    H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        492 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         493 CO.sub.2 C.sub.2 H.sub.5                                                              H         CHO          H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        494 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         495 "      "         COCH.sub.3   H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        496 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         497 "      "         SO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        498 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         499 "      CH.sub.3  CHO          H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        500 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         501 "      "         COCH.sub.3   H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        502 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         503 "      "         SO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        504 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         505 "      C.sub.2 H.sub.5                                                                          CHO          H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        506 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         507 "      "         COCH.sub.3   H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        508 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         509 "      "         SO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        510 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         511 "      OH        CHO          H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        512 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         513 "      "         COCH.sub.3   H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        514 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         515 "      "         SO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        516 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         517 "      OCH.sub.3 CHO          H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        518 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         519 "      "         COCH.sub.3   H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        520 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         521 CO.sub.2 -n-Bu                                                                        H         CHO          H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        522 CON(CH.sub.3).sub.2                                                                   CH.sub.3  CHO          H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         523 CONHCH.sub.3                                                                          H         CHO          H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        524 COSCH.sub.3                                                                           CH.sub.3  COCH.sub.3   H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         525 CO.sub.2 CH.sub.3                                                                     n-Bu      CHO          H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        526 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         527 "      H         "            H   OCH.sub.2 CF.sub.3                                                                    N(CH.sub.3).sub.2                                                                      N                         528 "      CH.sub.3  "            H   "      "       N                         529 "      H         COCH.sub.3   H   "      "       "                         530 "      CH.sub.3  "            H   "      "       "                         531 "      "         SO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        532 "      "         "            H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         533 CO.sub.2 CH.sub.3                                                                      ##STR19##             H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        534 "      "                      H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         535 CO.sub.2 CH.sub.3                                                                     CH.sub.3  CHO          H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  Na-Salt:                                                                       236-238               536 CO.sub.2 CH.sub.3                                                                     H         SO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  Na-Salt:                                                                       170-173               537 CO.sub.2 CH.sub.3                                                                     CH.sub.3  SO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  Na-Salt-:                                                                      191                   538 CO.sub.2 CH.sub.3                                                                     OCH.sub.3 CHO          H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  Na-Salt:                                                                       215-216               539 CO.sub.2 CH.sub.3                                                                     OCH.sub.3 COCH.sub.3   H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  Na-Salt:                                                                       224-225               540 CO.sub.2 CH.sub.3                                                                     H         COOCH.sub.5  H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  Na-Salt:                                                                       203-205               541 CO.sub.2 CH.sub.3                                                                     CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                  H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  Na-Salt:                                                                       122                   542 CO.sub.2 CH.sub.3                                                                     CH.sub.3  CONHEt       H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  Na-Salt:                                                                       190-192               543 CO.sub.2 CH.sub.3                                                                     CH.sub.3  CONHEt       H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  150-152               544 CO.sub.2 CH.sub.3                                                                     CH.sub.3  CONHEt       H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         545 CO.sub.2 CH.sub.3                                                                     H         CONHEt       H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        546 CO.sub.2 CH.sub.3                                                                     H         CONHEt       H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         547 CO.sub.2 CH.sub.3                                                                               COCH.sub.2 CH.sub.2 CO                                                                      H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  220-221               548 CO.sub.2 CH.sub.3                                                                               COCH.sub.2 CH.sub.2 CO                                                                      H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                         549 CO.sub.2 CH.sub.3                                                                               COCH.sub.2 CH.sub.2 CO                                                                      H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                        550 CO.sub.2 CH.sub.3                                                                               COCH.sub.2 CH.sub.2 CO                                                                      H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         551 CO.sub.2 CH.sub.3                                                                               COCH.sub.2 CH.sub.2 CO                                                                      H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  Na-Salt:                                                                       210-212               552 CO.sub.2 CH.sub.3                                                                     OCH.sub.3 COCF.sub.3   H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  Na-Salt:                                                                       228-229               553 CO.sub.2 CH.sub.3                                                                     OCH.sub.3 COOCH.sub.3  H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  Na-Salt:                                                                       184-185               554 CO.sub.2 CH.sub.3                                                                     OCH.sub.3 Cyclopropyl  H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  Na-Salt:                                                                       216                   555 CO.sub.2 CH.sub.3                                                                     OCH.sub.3 SO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  Na-Salt:                                                                       183-185               556 CO.sub.2 CH.sub.3                                                                     C.sub.2 H.sub.5                                                                          CHO          H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  Na-Salt:                                                                       237-239               557 CO.sub.2 CH.sub.3                                                                     C.sub.2 H.sub.5                                                                          Cyclopropyl  H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  Na-Salt:                                                                       178-180               558 CO.sub.2 CH.sub.3                                                                     C.sub.2 H.sub.5                                                                          COCCl.sub.3  H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  109-111               559 CO.sub.2 CH.sub.3                                                                     C.sub.2 H.sub.5                                                                          COCCl.sub.3  H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  Na-Salt:                                                                       174-176               560 CO.sub.2 CH.sub.3                                                                     C.sub.2 H.sub.5                                                                          COCCl.sub.3  H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         561 CO.sub.2 CH.sub.3                                                                     C.sub.2 H.sub.5                                                                          COCOOCH.sub.3                                                                               H   OCH.sub.3                                                                             CH.sub.3                                                                               N                         562 CO.sub.2 CH.sub.3                                                                     C.sub.2 H.sub.5                                                                          COCOOCH.sub.3                                                                               H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  138-140               563 CO.sub.2 CH.sub.3                                                                     C.sub.2 H.sub.5                                                                          COCH.sub.2 OCH.sub.3                                                                        H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  121-123               564 CO.sub.2 CH.sub.3                                                                     C.sub.2 H.sub.5                                                                          COCH.sub.2 OCH.sub.3                                                                        H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                        565 CO.sub.2 CH.sub.3                                                                     C.sub.2 H.sub.5                                                                          SO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  154-155               566 CO.sub.2 CH.sub.3                                                                     C.sub.2 H.sub.5                                                                          SO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  Na-Salt:                                                                       161                   567 CO.sub.2 CH.sub.3                                                                     C.sub.2 H.sub.5                                                                          SO.sub.2 NHCH.sub.3                                                                         H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  150-152               568 CO.sub.2 CH.sub.3                                                                     C.sub.2 H.sub.5                                                                          SO.sub.2 NHCH.sub.3                                                                         H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  Na-Salt:                                                                       165-168               569 CO.sub.2 CH.sub.3                                                                     OC.sub.2 H.sub.5                                                                         SO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  163-164               570 CO.sub.2 CH.sub.3                                                                     OC.sub.2 H.sub.5                                                                         SO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  Na-Salt:                                                                       166-168               571 CO.sub.2 CH.sub.3                                                                     OC.sub.2 H.sub.5                                                                         CHO          H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  165-166               572 CO.sub.2 CH.sub.3                                                                     OC.sub.2 H.sub.5                                                                         CHO          H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  No-Salt:                                                                       207-208               573 CO.sub.2 CH.sub.3                                                                     OCH.sub.3 CONHPh       H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  178-179               574 CO.sub.2 CH.sub.3                                                                     OCH.sub.3 CONHEt       H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  155-157               575 CO.sub.2 CH.sub.3                                                                     OCH.sub.3 COCCl.sub.3  H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  165-168               576 CO.sub.2 CH.sub.3                                                                     OCH.sub.3 COCCl.sub.3  H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  Na-Salt:                                                                       100                   577 CO.sub.2 CH.sub.3                                                                     OCH.sub.3 COCHCl.sub.2 H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  145-150               578 CO.sub.2 CH.sub.3                                                                     OCH.sub.3 COCHCl.sub.2 H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH  Na-Salt:                                                                       235                   __________________________________________________________________________

                                      TABLE 2                                      __________________________________________________________________________      ##STR20##                                                                     CN R.sup.1                                                                              R.sup.4  R.sup.5   R.sup.7                                                                             X    Y     Z  Mp. °C.                  __________________________________________________________________________     1  CO.sub.2 CH.sub.3                                                                    H        CHO       H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH 142-144                         2  "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 3  "     "        "         H    CH.sub.3                                                                            CH.sub.3                                                                             CH                                 4  "     "        "         H    CH.sub.3                                                                            OC.sub.2 H.sub.5                                                                     CH                                 5  "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  6  "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  7  "     "        "         H    OCH.sub.3                                                                           Cl    CH                                 8  "     "        "         H    OCF.sub.2 H                                                                         CH.sub.3                                                                             CH                                 9  "     "        "         H    OCF.sub.2 H                                                                         OCF.sub.2 H                                                                          CH                                 10 "     "        "         H    OCH.sub.3                                                                           Br    CH                                 11 "     "        "         H    OCH.sub.3                                                                           OC.sub.2 H.sub.5                                                                     CH                                 12 "     "        "         H    OCH.sub.3                                                                           SCH.sub.3                                                                            CH                                 13 "     "        "         H    OCH.sub.3                                                                           OC.sub.2 H.sub.5                                                                     N                                  14 "     "        "         H    OCH.sub.3                                                                           OC.sub.3 H.sub.7                                                                     CH                                 15 "     "        "         H    CH.sub.3                                                                            Cl    CH                                 16 "     "        "         H    Cl   OC.sub.2 H.sub.5                                                                     CH                                 17 "     "        "         H    OC.sub.2 H.sub.5                                                                    OC.sub.2 H.sub.5                                                                     CH                                 18 "     "        "         H    C.sub.2 H.sub.5                                                                     OCH.sub.3                                                                            CH                                 19 "     "        "         H    CF.sub.3                                                                            OCH.sub.3                                                                            CH                                 20 "     "        "         H    OCH.sub.2 CF.sub.3                                                                  CH.sub.3                                                                             CH                                 21 "     "        "         H    OCH.sub.2 CF.sub.3                                                                  OCH.sub.3                                                                            CH                                 22 "     "        "         H    OCH.sub.2 CF.sub.3                                                                  OCH.sub.2 CF.sub.3                                                                   CH                                 23 "     "        "         H    OCH.sub.2 CF.sub.3                                                                  OCH.sub.3                                                                            N                                  24 "     "        "         H    OCH.sub.3                                                                           CH(OCH.sub.3).sub.2                                                                  CH                                 25 "     "        "         CH.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 26 "     "        "         CH.sub.3                                                                            OCH.sub.3                                                                           CH.sub.3                                                                             N                                  27 "     H        COCH.sub.3                                                                               H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH 167-169                         28 "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 29 "     "        "         H    CH.sub.3                                                                            CH.sub.3                                                                             CH                                 30 "     "        "         H    CH.sub.3                                                                            OC.sub.2 H.sub.5                                                                     CH                                 31 "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  32 "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  33 "     "        "         H    OCH.sub.3                                                                           Cl    CH                                 34 "     "        "         H    OCF.sub.2 H                                                                         CH.sub.3                                                                             CH                                 35 "     "        "         H    OCF.sub.2 H                                                                         OCF.sub.2 H                                                                          CH                                 36 "     "        "         H    OCH.sub.3                                                                           Br    CH                                 37 "     "        "         H    OCH.sub.3                                                                           OC.sub.2 H.sub.5                                                                     CH                                 38 "     "        "         H    OCH.sub.3                                                                           SCH.sub.3                                                                            CH                                 39 "     "        "         H    OCH.sub.3                                                                           OC.sub.2 H.sub.5                                                                     N                                  40 "     "        "         H    OCH.sub.3                                                                           OC.sub.3 H.sub.7                                                                     CH                                 41 "     "        "         H    CH.sub.3                                                                            Cl    CH                                 42 "     "        "         H    Cl   OC.sub.2 H.sub.5                                                                     CH                                 43 "     "        "         H    OC.sub.2 H.sub.5                                                                    OC.sub.2 H.sub.5                                                                     CH                                 44 "     "        "         H    C.sub.2 H.sub.5                                                                     OCH.sub.3                                                                            CH                                 45 "     "        "         H    CF.sub.3                                                                            OCH.sub.3                                                                            CH                                 46 "     "        "         H    OCH.sub.2 CF.sub.3                                                                  CH.sub.3                                                                             CH                                 47 "     "        "         H    OCH.sub.2 CF.sub.3                                                                  OCH.sub.3                                                                            CH                                 48 "     "        "         H    OCH.sub.2 CF.sub.3                                                                  OCH.sub.2 CF.sub.3                                                                   CH                                 49 "     "        "         H    OCH.sub.2 CF.sub.3                                                                  OCH.sub.3                                                                            N                                  50 "     "        "         H    OCH.sub.3                                                                           CH(OCH.sub.3).sub.2                                                                  CH                                 51 "     "        "         CH.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 52 "     "        "         CH.sub.3                                                                            OCH.sub.3                                                                           CH.sub.3                                                                             N                                  53 "     CH.sub.3 CHO       H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH 160-162                         54 "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 55 "     "        "         H    CH.sub.3                                                                            CH.sub.3                                                                             CH                                 56 "     "        "         H    CH.sub.3                                                                            OC.sub.2 H.sub.5                                                                     CH                                 57 "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  58 "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  59 "     "        "         H    OCH.sub.3                                                                           Cl    CH                                 60 "     "        "         H    OCF.sub.2 H                                                                         CH.sub.3                                                                             CH                                 61 "     "        "         H    OCF.sub.2 H                                                                         OCF.sub.2 H                                                                          CH                                 62 "     "        "         H    OCH.sub.3                                                                           Br    CH                                 63 "     "        "         H    OCH.sub.3                                                                           OC.sub.2 H.sub.5                                                                     CH                                 64 "     "        "         H    OCH.sub.3                                                                           SCH.sub.3                                                                            CH                                 65 "     "        "         H    OCH.sub.3                                                                           OC.sub.2 H.sub.5                                                                     N                                  66 "     "        "         H    OCH.sub.3                                                                           OC.sub.3 H.sub.7                                                                     CH                                 67 "     "        "         F    CH.sub.3                                                                            Cl    CH                                 68 "     "        "         H    Cl   OC.sub.2 H.sub.5                                                                     CH                                 69 "     "        "         H    OC.sub.2 H.sub.5                                                                    OC.sub.2 H.sub.5                                                                     CH                                 70 "     "        "         H    C.sub.2 H.sub.5                                                                     OCH.sub.3                                                                            CH                                 71 "     "        "         H    CF.sub.3                                                                            OCH.sub.3                                                                            CH                                 72 "     "        "         H    OCH.sub.2 CF.sub.3                                                                  CH.sub.3                                                                             CH                                 73 "     "        "         H    OCH.sub.2 CF.sub.3                                                                  OCH.sub.3                                                                            CH                                 74 "     "        "         H    OCH.sub.2 CF.sub.3                                                                  OCH.sub.2 CF.sub.3                                                                   CH                                 75 "     "        "         H    OCH.sub.2 CF.sub.3                                                                  OCH.sub.3                                                                            N                                  76 "     "        "         H    OCH.sub.3                                                                           CH(OCH.sub.3).sub.2                                                                  CH                                 77 "     "        "         CH.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 78 "     "        "         CH.sub.3                                                                            OCH.sub.3                                                                           CH.sub.3                                                                             N                                  79 "     CH.sub.3 COCH.sub.3                                                                               H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH 166-168                         80 "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 81 "     "        "         H    CH.sub.3                                                                            CH.sub.3                                                                             CH                                 82 "     "        "         H    CH.sub.3                                                                            OC.sub.2 H.sub.5                                                                     CH                                 83 "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  84 "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  85 "     "        "         H    OCH.sub.3                                                                           Cl    CH                                 86 "     "        "         H    OCF.sub.2 H                                                                         CH.sub.3                                                                             CH                                 87 "     "        "         H    OCF.sub.2 H                                                                         OCF.sub.2 H                                                                          CH                                 88 "     "        "         H    OCH.sub.3                                                                           Br    CH                                 89 "     "        "         H    OCH.sub.3                                                                           OC.sub.2 H.sub.5                                                                     CH                                 90 "     "        "         H    OCH.sub.3                                                                           SCH.sub.3                                                                            CH                                 91 "     "        "         H    OCH.sub.3                                                                           OC.sub.2 H.sub.5                                                                     N                                  92 "     "        "         H    OCH.sub.3                                                                           OC.sub.3 H.sub.7                                                                     CH                                 93 "     "        "         H    CH.sub.3                                                                            Cl    CH                                 94 "     "        "         H    Cl   OC.sub.2 H.sub.5                                                                     CH                                 95 "     "        "         H    OC.sub.2 H.sub.5                                                                    OC.sub.2 H.sub.5                                                                     CH                                 96 "     "        "         H    C.sub.2 H.sub.5                                                                     OCH.sub.3                                                                            CH                                 97 "     "        "         H    CF.sub.3                                                                            OCH.sub.3                                                                            CH                                 98 "     "        "         H    OCH.sub.2 CF.sub.3                                                                  CH.sub.3                                                                             CH                                 99 "     "        "         H    OCH.sub.2 CF.sub.3                                                                  OCH.sub.3                                                                            CH                                 100                                                                               "     "        "         H    OCH.sub.2 CF.sub.3                                                                  OCH.sub.2 CF.sub.3                                                                   CH                                 101                                                                               "     "        "         H    OCH.sub.2 CF.sub.3                                                                  OCH.sub.3                                                                            N                                  102                                                                               "     "        "         H    OCH.sub.3                                                                           CH(OCH.sub.3).sub.2                                                                  CH                                 103                                                                               "     "        "         CH.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 104                                                                               "     "        "         CH.sub.3                                                                            OCH.sub.3                                                                           CH.sub.3                                                                             N                                  105                                                                               "     H        SO.sub.2 CH.sub.3                                                                        H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 106                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 107                                                                               "     "        "         H    CH.sub.3                                                                            CH.sub.3                                                                             CH                                 108                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  109                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  110                                                                               "     "        "         H    OC.sub.2 H.sub.5                                                                    NHCH.sub.3                                                                           N                                  111                                                                               "     "        "         CH.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 112                                                                               "     "        "         CH.sub.3                                                                            OCH.sub.3                                                                           CH.sub.3                                                                             N                                  113                                                                               "     CH.sub.3 SO.sub.2 CH.sub.3                                                                        H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 114                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 115                                                                               "     "        "         H    CH.sub.3                                                                            CH.sub.3                                                                             CH                                 116                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  117                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  118                                                                               "     "        "         H    OC.sub.2 H.sub.5                                                                    NHCH.sub.3                                                                           N                                  119                                                                               "     "        "         CH.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 120                                                                               "     "        "         CH.sub.3                                                                            OCH.sub.3                                                                           CH.sub.3                                                                             N                                  121                                                                               "     OH       CHO       H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 122                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 123                                                                               "     "        "         H    CH.sub.3                                                                            CH.sub.3                                                                             CH                                 124                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  125                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  126                                                                               "     "        "         H    OC.sub.2 H.sub.5                                                                    NHCH.sub.3                                                                           N                                  127                                                                               "     "        "         CH.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 128                                                                               "     "        "         CH.sub.3                                                                            OCH.sub.3                                                                           CH.sub.3                                                                             N                                  129                                                                               "     OCH.sub.3                                                                               CHO       H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 130                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 131                                                                               "     "        "         H    CH.sub.3                                                                            CH.sub.3                                                                             CH                                 132                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  133                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  134                                                                               "     "        "         H    OC.sub.2 H.sub.5                                                                    NHCH.sub.3                                                                           N                                  135                                                                               "     "        "         CH.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 136                                                                               "     "        "         CH.sub.3                                                                            OCH.sub.3                                                                           CH.sub.3                                                                             N                                  137                                                                               "     OH       COCH.sub.3                                                                               H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 138                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 139                                                                               "     "        "         H    CH.sub.3                                                                            CH.sub.3                                                                             CH                                 140                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  141                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  142                                                                               "     "        "         H    OC.sub.2 H.sub.5                                                                    NHCH.sub.3                                                                           N                                  143                                                                               "     "        "         CH.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 144                                                                               "     "        "         CH.sub.3                                                                            OCH.sub.3                                                                           CH.sub.3                                                                             N                                  145                                                                               "     OCH.sub.3                                                                               COCH.sub.3                                                                               H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 146                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 147                                                                               "     "        "         H    CH.sub.3                                                                            CH.sub.3                                                                             CH                                 148                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  149                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  150                                                                               "     "        "         H    OC.sub.2 H.sub.5                                                                    NHCH.sub.3                                                                           N                                  151                                                                               "     "        "         CH.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 152                                                                               "     "        "         CH.sub.3                                                                            OCH.sub.3                                                                           CH.sub.3                                                                             N                                  153                                                                               "     H        COC.sub.2 H.sub.5                                                                        H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH 196                             154                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 155                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  156                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  157                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 158                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 159                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  160                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  161                                                                               "     H        COCH.sub.2 OCH.sub.3                                                                     H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH 192-195                         162                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 163                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  164                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  165                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 166                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 167                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  168                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  169                                                                               "     H        COCO.sub.2 C.sub.2 H.sub.5                                                               H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH 183-185                         170                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 171                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  172                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  173                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 174                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 175                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  176                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  177                                                                               "     H        COCF.sub.3                                                                               H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH 180-182                         178                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 179                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  180                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  181                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH 144-147                         182                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 183                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  184                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  185                                                                               "     H        COOCH.sub.3                                                                              H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH 178-180                         186                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 187                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  188                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  189                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 190                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 191                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  192                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  193                                                                               "     H        CONHC.sub.2 H.sub.5                                                                      H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 194                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 195                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  196                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  197                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 198                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 199                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  200                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  201                                                                               "     H        CSNHC.sub.2 H.sub.5                                                                      H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 202                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 203                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  204                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  205                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 206                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 207                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  208                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  209                                                                               "     H        SO.sub.2 NHCH.sub.3                                                                      H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 210                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 211                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  212                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  213                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 214                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 215                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  216                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  217                                                                               "     H        SO.sub.2 N(CH.sub.3).sub.2                                                               H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 218                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 219                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  220                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  221                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 222                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 223                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  224                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  225                                                                               "     CH.sub.2 CH.sub.2 CH.sub.2 CO                                                                     H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 226                                                                               "     "                  H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 227                                                                               "     "                  H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  228                                                                               "     "                  H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  229                                                                               "     CH.sub.2 CH.sub.2 CH.sub.2 SO.sub.2                                                               H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 230                                                                               "     "                  H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 231                                                                               "     "                  H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  232                                                                               "     "                  H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  233                                                                               "     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CO                                                            H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 234                                                                               "     "                  H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 235                                                                               "     "                  H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  236                                                                               "     "                  H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  237                                                                               "     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 SO.sub.2                                                      H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 238                                                                               "     "                  H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 239                                                                               "     "                  H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  240                                                                               "     "                  H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  241                                                                               "     CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                                              H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 242                                                                               "     "                  H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 243                                                                               "     "                  H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  244                                                                               "     "                  H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  245                                                                               "     H        COC.sub.3 H.sub.7                                                                        H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 246                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 247                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  248                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  249                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 250                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 251                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  252                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  253                                                                               "     H        COCH.sub.2 Cl                                                                            H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH 170-172                         254                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 255                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  256                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  257                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 258                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 259                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  260                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  261                                                                               "     H        COCHCl.sub.2                                                                             H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH 158-160                         262                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 263                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  264                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  265                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 266                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 267                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  268                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  269                                                                               "     H        COCCl.sub.3                                                                              H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH 194-196                         270                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 271                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  272                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  273                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 274                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 275                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  276                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  277                                                                               "     H        COCHCH.sub.2                                                                             H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 278                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 279                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  280                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  281                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 282                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 283                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  284                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  285                                                                               "     H        COCCH     H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 286                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 287                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  287                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  289                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 290                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 291                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  292                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  293                                                                               "     H        COC.sub.6 H.sub.5                                                                        H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 294                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 295                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  296                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  297                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 298                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 299                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  300                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  301                                                                               "     SO.sub.2 C.sub.6 H.sub.5                                                                SO.sub.2 C.sub.6 H.sub.5                                                                 H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 302                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 303                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  304                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  305                                                                               "     SO.sub.2 CH.sub.3                                                                       SO.sub.2 CH.sub.3                                                                        H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 306                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 307                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  308                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  309                                                                               "     H        COCH.sub.2 Br                                                                            H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 310                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  311                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 312                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  313                                                                               "     H        COCH.sub.2 F                                                                             H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 314                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  315                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 316                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  317                                                                               "     H        COCH.sub.2 CH                                                                            H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 318                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  319                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 320                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  321                                                                               "     H        COCO.sub.2 CH.sub.3                                                                      H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 322                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  323                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 324                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  325                                                                               "     H        CO.sub.2 C.sub.2 H.sub.5                                                                 H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 326                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  327                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 328                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  329                                                                               "     H        COSCH.sub.3                                                                              H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 330                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  331                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 332                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  333                                                                               "     H        CSOCH.sub.3                                                                              H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 334                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  335                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 336                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  337                                                                               "     H        CSSCH.sub.3                                                                              H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 338                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  339                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 340                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  341                                                                               "     H        COCH(CH.sub.3).sub.2                                                                     H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH 195-196                         342                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  343                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 344                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  345                                                                               "     H        COC(CH.sub.3).sub.3                                                                      H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 346                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  347                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 348                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  349                                                                               "     H        CO-Cyclopropyl                                                                           H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH 202-203                         350                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  351                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 352                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  353                                                                               "     H        CO-Cyclobutyl                                                                            H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 354                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  355                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 356                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  357                                                                               "     H        CO-Cyclopentyl                                                                           H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 358                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  359                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 360                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  361                                                                               "     H        CO-Cyclohexyl                                                                            H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 362                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  363                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 364                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  365                                                                               "     H        CONHCH.sub.2 CH.sub.2 Cl                                                                 H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH 178-182                         366                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  367                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 368                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  369                                                                               "     H        CSNHCH.sub.2 CH.sub.2 Cl                                                                 H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 370                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  371                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 372                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  373                                                                               "     H        CONH-n-C.sub.4 H.sub.9                                                                   H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH 183-184                         374                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  375                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 376                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  377                                                                               "     H        CSNHCH.sub.3                                                                             H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 378                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  379                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 380                                                                               "     "        "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 381                                                                               "     H        CSNHCH.sub.2 CHCH.sub.2                                                                  H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 382                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             CH                                 383                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 384                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  385                                                                               "     CH.sub.3 CSNHCH.sub.2 COCH.sub.3                                                                  H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 386                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  387                                                                               "     CH.sub.3 CSNHCH.sub.2 COC.sub.2 H.sub.5                                                           H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 388                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  389                                                                               "     CH.sub.3 CONHCH.sub.2 COCH.sub.3                                                                  H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 390                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  391                                                                               "     CH.sub.3 CONHCH.sub.2 COC.sub.2 H.sub.5                                                           H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 392                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  393                                                                               "     CONHCH.sub.2 CO    H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 394                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  395                                                                               "     H        SO.sub.2 CH.sub.2 F                                                                      H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 396                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  397                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 398                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  399                                                                               "     H        SO.sub.2 CF.sub.3                                                                        H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 400                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  401                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 402                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  403                                                                               "     H        SO.sub.2 C.sub.2 H.sub.5                                                                 H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 404                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  405                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 406                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  407                                                                               "     H        SO.sub.2 -n-C.sub.3 H.sub.7                                                              H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 408                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  409                                                                               "     CH.sub.3 "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 410                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  411                                                                               "     OH       COC.sub.2 H.sub.5                                                                        H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 412                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  413                                                                               "     OCH.sub.3                                                                               "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 414                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  415                                                                               "     OH       COCH.sub.2 Cl                                                                            H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 416                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  417                                                                               "     OCH.sub.3                                                                               "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 418                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  419                                                                               "     OH       COCF.sub.3                                                                               H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 420                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  421                                                                               "     OCH.sub.3                                                                               "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 422                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  423                                                                               "     OH       COCH.sub.2 OCH.sub.3                                                                     H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 424                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  425                                                                               "     OCH.sub.3                                                                               "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 426                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  427                                                                               "     OH       COCO.sub.2 C.sub.2 H.sub.5                                                               H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 428                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  429                                                                               "     OCH.sub.3                                                                               "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 430                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  431                                                                               "     OH       COOCH.sub.3                                                                              H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 432                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  433                                                                               "     OCH.sub.3                                                                               "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 434                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  435                                                                               "     OH       Cyclopropyl                                                                              H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 436                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  437                                                                               "     OCH.sub.3                                                                               "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 438                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  439                                                                               "     OH       COC.sub.6 H.sub.5                                                                        H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 440                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  441                                                                               "     OCH.sub.3                                                                               "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 442                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  443                                                                               "     OH       COCH(CH.sub.3).sub.2                                                                     H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 444                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  445                                                                               "     OCH.sub.3                                                                               "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 446                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  447                                                                               "     OH       COCHCH.sub.2                                                                             H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 448                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  449                                                                               "     OCH.sub.3                                                                               "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 450                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  451                                                                               "     OH       COCCH     H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 452                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  453                                                                               "     OCH.sub.3                                                                               "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 454                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  455                                                                               "     OH       SO.sub.2 CH.sub.3                                                                        H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 456                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  457                                                                               "     OCH.sub.3                                                                               "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 458                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  459                                                                               "     OH       SO.sub.2 NHCH.sub.3                                                                      H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 460                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  461                                                                               "     OCH.sub.3                                                                               "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 462                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  463                                                                               "     OH       SO.sub.2 N(CH.sub.3).sub.2                                                               H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 464                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  465                                                                               "     OCH.sub.3                                                                               "         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 466                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  467                                                                               "     C.sub.2 H.sub.5                                                                         CHO       H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 468                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  469                                                                               "     "        COCH.sub.3                                                                               H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 470                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  471                                                                               "     "        Cyclopropyl                                                                              H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 472                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  473                                                                               "     "        COOCH.sub.2 Cl                                                                           H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 474                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  475                                                                               "     "        COCF.sub.3                                                                               H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 476                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  477                                                                               "     "        COOCH.sub.3                                                                              H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 478                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  479                                                                               "     "        COC.sub.6 H.sub.5                                                                        H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 480                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  481                                                                               "     "        CONHC.sub.2 H.sub.5                                                                      H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 482                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  483                                                                               "     "        CSNHC.sub.2 H.sub.5                                                                      H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 484                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  485                                                                               "     "        SO.sub.2 CH.sub.3                                                                        H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 486                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  487                                                                               "     "        SO.sub.2 NHCH.sub.3                                                                      H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 488                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  489                                                                               "     "        SO.sub.2 N(CH.sub.3).sub.2                                                               H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 490                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  491                                                                               "     "        SO.sub.2 COH.sub.5                                                                       H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 492                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  493                                                                               CO.sub.2 C.sub.2 H.sub.5                                                             H        CHO       H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 494                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  495                                                                               "     "        COCH.sub.3                                                                               H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 496                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  497                                                                               "     "        SO.sub.2 CH.sub.3                                                                        H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 498                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  499                                                                               "     CH.sub.3 CHO       H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 500                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  501                                                                               "     "        COCH.sub.3                                                                               H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 502                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  503                                                                               "     "        SO.sub.2 CH.sub.3                                                                        H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 504                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  505                                                                               "     C.sub.2 H.sub.5                                                                         CHO       H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 506                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  507                                                                               "     "        COCH.sub.3                                                                               H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 508                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  509                                                                               "     "        SO.sub.2 CH.sub.3                                                                        H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 510                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  511                                                                               "     OH       CHO       H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 512                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  513                                                                               "     "        COCH.sub.3                                                                               H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 514                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  515                                                                               "     "        SO.sub.2 CH.sub.3                                                                        H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 516                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  517                                                                               "     OCH.sub.3                                                                               CHO       H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 518                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  519                                                                               "     "        COCH.sub.3                                                                               H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 520                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  521                                                                               CO.sub.2 -n-Bu                                                                       H        CHO       H    "    OMe   CH                                 522                                                                               CONMe.sub.2                                                                          Me       "         H    "    Me    N                                  523                                                                               CONHMe                                                                               H        "         H    "    OMe   CH                                 524                                                                               COSMe Me       CO-Me     H    "    Me    N                                  525                                                                               CO.sub.2 Me                                                                          n-Bu     CHO       H    "    OMe   CH                                 526                                                                               "     n-Bu     "         H    "    Me    N                                  527                                                                               "     H        "         H    OCH.sub.2 CF.sub.3                                                                  NMe.sub.2                                                                            "                                  528                                                                               "     Me       "         H    "    "     "                                  529                                                                               "     H        CO-Me     H    "    "     "                                  530                                                                               "     Me       "         H    "    "     "                                  531                                                                               "     "        SO.sub.2 CH.sub.3                                                                        H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 532                                                                               "     "        "         H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  533                                                                               "                                                                                     ##STR21##         H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 534                                                                               "     "                  H    OCH.sub.3                                                                           CH.sub.3                                                                             N                                  __________________________________________________________________________

                                      TABLE 3                                      __________________________________________________________________________      ##STR22##                                                                     CN R.sup.1                                                                              R.sup.4  R.sup.5   R.sup.7                                                                           X     Y     Z  Mp. °C.                   __________________________________________________________________________     1  CO.sub.2 CH.sub.3                                                                    H        CHO       H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  2  "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  3  "     "        "         H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                  4  "     "        "         H  CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                     CH                                  5  "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   6  "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   7  "     "        "         H  OCH.sub.3                                                                            Cl    CH                                  8  "     "        "         H  OCF.sub.2 H                                                                          CH.sub.3                                                                             CH                                  9  "     "        "         H  OCF.sub.2 H                                                                          OCF.sub.2 H                                                                          CH                                  10 "     "        "         H  OCH.sub.3                                                                            Br    CH                                  11 "     "        "         H  OCH.sub.3                                                                            OC.sub.2 H.sub.5                                                                     CH                                  12 "     "        "         H  OCH.sub.3                                                                            SCH.sub.3                                                                            CH                                  13 "     "        "         H  OCH.sub.3                                                                            OC.sub.2 H.sub.5                                                                     N                                   14 "     "        "         H  OCH.sub.3                                                                            OC.sub.3 H.sub.7                                                                     CH                                  15 "     "        "         H  CH.sub.3                                                                             Cl    CH                                  16 "     "        "         H  Cl    OC.sub.2 H.sub.5                                                                     CH                                  17 "     "        "         H  OC.sub.2 H.sub.5                                                                     OC.sub.2 H.sub.5                                                                     CH                                  18 "     "        "         H  C.sub.2 H.sub.5                                                                      OCH.sub.3                                                                            CH                                  19 "     "        "         H  CF.sub.3                                                                             OCH.sub.3                                                                            CH                                  20 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   CH.sub.3                                                                             CH                                  21 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                            CH                                  22 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.2 CF.sub.3                                                                   CH                                  23 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                            N                                   24 "     "        "         H  OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                  CH                                  25 "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  26 "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.3                                                                             N                                   27 "     H        COCH.sub.3                                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH 198-200                          28 "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  29 "     "        "         H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                  30 "     "        "         H  CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                     CH                                  31 "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   32 "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   33 "     "        "         H  OCH.sub.3                                                                            Cl    CH                                  34 "     "        "         H  OCF.sub.2 H                                                                          CH.sub.3                                                                             CH                                  35 "     "        "         H  OCF.sub.2 H                                                                          OCF.sub.2 H                                                                          CH                                  36 "     "        "         H  OCH.sub.3                                                                            Br    CH                                  37 "     "        "         H  OCH.sub.3                                                                            OC.sub.2 H.sub.5                                                                     CH                                  38 "     "        "         H  OCH.sub.3                                                                            SCH.sub.3                                                                            CH                                  39 "     "        "         H  OCH.sub.3                                                                            OC.sub.2 H.sub.5                                                                     N                                   40 "     "        "         H  OCH.sub.3                                                                            OC.sub.3 H.sub.7                                                                     CH                                  41 "     "        "         H  CH.sub.3                                                                             Cl    CH                                  42 "     "        "         H  Cl    OC.sub.2 H.sub.5                                                                     CH                                  43 "     "        "         H  OC.sub.2 H.sub.5                                                                     OC.sub.2 H.sub.5                                                                     CH                                  44 "     "        "         H  C.sub.2 H.sub.5                                                                      OCH.sub.3                                                                            CH                                  45 "     "        "         H  CF.sub.3                                                                             OCH.sub.3                                                                            CH                                  46 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   CH.sub.3                                                                             CH                                  47 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                            CH                                  48 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.2 CF.sub.3                                                                   CH                                  49 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                            N                                   50 "     "        "         H  OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                  CH                                  51 "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  52 "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.3                                                                             N                                   53 "     CH.sub.3 CHO       H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  54 "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  55 "     "        "         H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                  56 "     "        "         H  CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                     CH                                  57 "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   58 "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   59 "     "        "         H  OCH.sub.3                                                                            Cl    CH                                  60 "     "        "         H  OCF.sub.2 H                                                                          CH.sub.3                                                                             CH                                  61 "     "        "         H  OCF.sub.2 H                                                                          OCF.sub.2 H                                                                          CH                                  62 "     "        "         H  OCH.sub.3                                                                            Br    CH                                  63 "     "        "         H  OCH.sub.3                                                                            OC.sub.2 H.sub.5                                                                     CH                                  64 "     "        "         H  OCH.sub.3                                                                            SCH.sub.3                                                                            CH                                  65 "     "        "         H  OCH.sub.3                                                                            OC.sub.2 H.sub.5                                                                     N                                   66 "     "        "         H  OCH.sub.3                                                                            OC.sub.3 H.sub.7                                                                     CH                                  67 "     "        "         H  CH.sub.3                                                                             Cl    CH                                  68 "     "        "         H  Cl    OC.sub.2 H.sub.5                                                                     CH                                  69 "     "        "         H  OC.sub.2 H.sub.5                                                                     OC.sub.2 H.sub.5                                                                     CH                                  70 "     "        "         H  C.sub.2 H.sub.5                                                                      OCH.sub.3                                                                            CH                                  71 "     "        "         H  CF.sub.3                                                                             OCH.sub.3                                                                            CH                                  72 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   CH.sub.3                                                                             CH                                  73 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                            CH                                  74 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.2 CF.sub.3                                                                   CH                                  75 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                            N                                   76 "     "        "         H  OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                  CH                                  77 "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  78 "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.3                                                                             N                                   79 "     CH.sub.3 COCH.sub.3                                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  80 "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  81 "     "        "         H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                  82 "     "        "         H  CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                     CH                                  83 "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   84 "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   85 "     "        "         H  OCH.sub.3                                                                            Cl    CH                                  86 "     "        "         H  OCF.sub.2 H                                                                          CH.sub.3                                                                             CH                                  87 "     "        "         H  OCF.sub.2 H                                                                          OCF.sub.2 H                                                                          CH                                  88 "     "        "         H  OCH.sub.3                                                                            Br    CH                                  89 "     "        "         H  OCH.sub.3                                                                            OC.sub.2 H.sub.5                                                                     CH                                  90 "     "        "         H  OCH.sub.3                                                                            SCH.sub.3                                                                            CH                                  91 "     "        "         H  OCH.sub.3                                                                            OC.sub.2 H.sub.5                                                                     N                                   92 "     "        "         H  OCH.sub.3                                                                            OC.sub.3 H.sub.7                                                                     CH                                  93 "     "        "         H  CH.sub.3                                                                             Cl    CH                                  94 "     "        "         H  Cl    OC.sub.2 H.sub.5                                                                     CH                                  95 "     "        "         H  OC.sub.2 H.sub.5                                                                     OC.sub.2 H.sub.5                                                                     CH                                  96 "     "        "         H  C.sub.2 H.sub.5                                                                      OCH.sub.3                                                                            CH                                  97 "     "        "         H  CF.sub.3                                                                             OCH.sub.3                                                                            CH                                  98 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   CH.sub.3                                                                             CH                                  99 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                            CH                                  100                                                                               "     "        "         H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.2 CF.sub.3                                                                   CH                                  101                                                                               "     "        "         H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                            N                                   102                                                                               "     "        "         H  OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                  CH                                  103                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  104                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.3                                                                             N                                   105                                                                               "     H        SO.sub.2 CH.sub.3                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  106                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  107                                                                               "     "        "         H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                  108                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   109                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   110                                                                               "     "        "         H  OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                           N                                   111                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  112                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.3                                                                             N                                   113                                                                               "     CH.sub.3 SO.sub.2 CH.sub.3                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  114                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  115                                                                               "     "        "         H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                  116                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   117                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   118                                                                               "     "        "         H  OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                           N                                   119                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  120                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.3                                                                             N                                   121                                                                               "     OH       CHO       H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  122                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  123                                                                               "     "        "         H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                  124                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   125                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   126                                                                               "     "        "         H  OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                           N                                   127                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  128                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.3                                                                             N                                   129                                                                               "     OCH.sub.3                                                                               CHO       H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  130                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  131                                                                               "     "        "         H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                  132                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   133                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   134                                                                               "     "        "         H  OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                           N                                   135                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  136                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.3                                                                             N                                   137                                                                               "     OH       COCH.sub.3                                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  138                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  139                                                                               "     "        "         H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                  140                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   141                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   142                                                                               "     "        "         H  OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                           N                                   143                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  144                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.3                                                                             N                                   145                                                                               "     OCH.sub.3                                                                               COCH.sub.3                                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  146                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  147                                                                               "     "        "         H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                  148                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   149                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   150                                                                               "     "        "         H  OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                           N                                   151                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  152                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.3                                                                             N                                   153                                                                               "     H        COC.sub.2 H.sub.5                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  154                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  155                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   156                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   157                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  158                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  159                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   160                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   161                                                                               "     H        COCH.sub.2 OCH.sub.3                                                                     H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  162                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  163                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   164                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   165                                                                               "     CH.sub.3 "         N  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  166                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  167                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   168                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   169                                                                               "     H        COCO.sub.2 C.sub.2 H.sub.5                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  170                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  171                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   172                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   173                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  174                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  175                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   176                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   177                                                                               "     H        COCF.sub.3                                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  178                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  179                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   180                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   181                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  182                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  183                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   184                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   185                                                                               "     H        COOCH.sub.3                                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  186                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  187                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   188                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   189                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  190                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  191                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   192                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   193                                                                               "     H        CONHC.sub.2 H.sub.5                                                                      H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  194                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  195                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   196                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   197                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  198                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  199                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   200                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   201                                                                               "     H        CSNHC.sub.2 H.sub.5                                                                      H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  202                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  203                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   204                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   205                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  206                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  207                                                                               "     "        "         N  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   208                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   209                                                                               "     H        SO.sub.2 NHCH.sub.3                                                                      H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  210                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  211                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   212                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   213                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  214                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  215                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   216                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   217                                                                               "     H        SO.sub.2 N(CH.sub.3).sub.2                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  218                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  219                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   220                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   221                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  222                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  223                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   224                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   225                                                                               "     CH.sub.2 CH.sub.2 CH.sub.2 CO                                                                     H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  226                                                                               "     "                  H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  227                                                                               "     "                  H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   228                                                                               "     "                  H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   229                                                                               "     CH.sub.2 CH.sub.2 CH.sub.2 SO.sub.2                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  230                                                                               "     "                  H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  231                                                                               "     "                  H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   232                                                                               "     "                  H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   233                                                                               "     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CO                                                            H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  234                                                                               "     "                  H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  235                                                                               "     "                  H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   236                                                                               "     "                  H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   237                                                                               "     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 SO.sub.2                                                      H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  238                                                                               "     "                  H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  239                                                                               "     "                  H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   240                                                                               "     "                  H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   241                                                                               "     CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  242                                                                               "     "                  H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  243                                                                               "     "                  H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   244                                                                               "     "                  H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   245                                                                               "     H        COC.sub.3 H.sub.7                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  246                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  247                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   248                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   249                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  250                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  251                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   252                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   253                                                                               "     H        COCH.sub.2 Cl                                                                            H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  254                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  255                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   256                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   257                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  258                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  259                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   260                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   261                                                                               "     H        COCHCl.sub.2                                                                             H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  262                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  263                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   264                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   265                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  266                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  267                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   268                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   269                                                                               "     H        COCCl.sub.3                                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  270                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  271                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   272                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   273                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  274                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  275                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   276                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   277                                                                               "     H        COCCH.sub.2                                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  278                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  279                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   280                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   281                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  282                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  283                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   284                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   285                                                                               "     H        COCCH     H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  286                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  287                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   288                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   289                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  290                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  291                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   292                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   293                                                                               "     H        COC.sub.6 H.sub.5                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  294                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  295                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   296                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   297                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  298                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  299                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   300                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   301                                                                               "     SO.sub.2 C.sub.6 H.sub.5                                                                SO.sub.2 C.sub.6 H                                                                       H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  302                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  303                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   304                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   305                                                                               "     SO.sub.2 CH.sub.3                                                                       SO.sub.2 CH.sub.3                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  306                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  307                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   308                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   309                                                                               "     H        COCH.sub.2 Br                                                                            H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  310                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   311                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  312                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   313                                                                               "     H        COCH.sub.2 F                                                                             H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  314                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   315                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  316                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   317                                                                               "     H        COCH.sub.2 CCH                                                                           H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  318                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   319                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  320                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   321                                                                               "     H        COCO.sub.2 CH.sub.3                                                                      H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  322                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   323                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  324                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   325                                                                               "     H        CO.sub.2 C.sub.2 H.sub.5                                                                 H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  326                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   327                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  328                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   329                                                                               "     H        COSCH.sub.3                                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  330                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   331                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  332                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   333                                                                               "     H        CSOCH.sub.3                                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  334                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   335                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  336                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   337                                                                               "     H        CSSCH.sub.3                                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  338                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   339                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  340                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   341                                                                               "     H        COCH(CH.sub.3).sub.2                                                                     H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  342                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   343                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  344                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   345                                                                               "     H        COC(CH.sub.3).sub.3                                                                      H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  346                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   347                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  348                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   349                                                                               "     H        CO-Cyclopropyl                                                                           H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  350                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   351                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  352                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   353                                                                               "     H        CO-Cyclobutyl                                                                            H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  354                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   355                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  356                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   357                                                                               "     H        CO-Cyclopentyl                                                                           H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  358                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   359                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  360                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   361                                                                               "     H        CO-Cyclohexyl                                                                            H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  362                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   363                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  364                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   365                                                                               "     H        CONHCH.sub.2 CH.sub.2 Cl                                                                 H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  366                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   367                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  368                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   369                                                                               "     H        CSNHCH.sub.2 CH.sub.2 Cl                                                                 H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  370                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   371                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  372                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   373                                                                               "     H        CONH-n-C.sub.4 H.sub.9                                                                   H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  374                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   375                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  376                                                                               "     "        "         N  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   377                                                                               "     H        CSNHCH.sub.3                                                                             H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  378                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   379                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  380                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   381                                                                               "     H        CSNHCH.sub.2 CHCH.sub.2                                                                  H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  382                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   383                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  384                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   385                                                                               "     CH.sub.3 CSNHCH.sub.2 COCH.sub.3                                                                  H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  386                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   387                                                                               "     CH.sub.3 CSNHCH.sub.2 COC.sub.2 H.sub.5                                                           H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  388                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   389                                                                               "     CH.sub.3 CONHCH.sub.2 COCH.sub.3                                                                  H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  390                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   391                                                                               "     CH.sub.3 CONHCH.sub.2 COC.sub.2 H.sub.5                                                           H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  392                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   393                                                                               "     CONHCH.sub.2 CO    H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  394                                                                               "     "                  H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   395                                                                               "     H        SO.sub.2 CH.sub.2 F                                                                      H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  396                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   397                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  398                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   399                                                                               "     H        SO.sub.2 CF.sub.3                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  400                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   401                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  402                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   403                                                                               "     H        SO.sub.2 C.sub.2 H.sub.5                                                                 H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  404                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   405                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  406                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   407                                                                               "     H        SO.sub.2 -n-C.sub.3 H.sub.7                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  408                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   409                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  410                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   411                                                                               "     OH       COC.sub.2 H.sub.5                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  412                                                                               "     "        "         H  OCH.sub.2                                                                            CH.sub.3                                                                             N                                   413                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  414                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   415                                                                               "     OH       COCH.sub.2 Cl                                                                            H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  416                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   417                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  418                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   419                                                                               "     OH       COCF.sub.3                                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  420                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   421                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  422                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   423                                                                               "     OH       COCH.sub.2 OCH.sub.3                                                                     H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  424                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   425                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  426                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   427                                                                               "     OH       COCO.sub.2 C.sub.2 H.sub.5                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  428                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   429                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  430                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   431                                                                               "     OH       COOCH.sub.3                                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  432                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   433                                                                               "     OCH.sub.3                                                                               "         H  OCH   OCH.sub.3                                                                            CH                                  434                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   435                                                                               "     OH       Cyclopropyl                                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  436                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   437                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  438                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   439                                                                               "     OH       COC.sub.6 H.sub.5                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  440                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   441                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  442                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   443                                                                               "     OH       COCH(CH.sub.3).sub.2                                                                     H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  444                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   445                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  446                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   447                                                                               "     OH       COCHCH.sub.2                                                                             H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  448                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   449                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  450                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   451                                                                               "     OH       COCCH     H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  452                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   453                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  454                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   455                                                                               "     OH       SO.sub.2 CH.sub.3                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  456                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   457                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  458                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   459                                                                               "     OH       SO.sub.2 NHCH.sub.3                                                                      H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  460                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   461                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  462                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   463                                                                               "     OH       SO.sub.2 N(CH.sub.3).sub.2                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  464                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   465                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  466                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   467                                                                               "     C.sub.2 H.sub.5                                                                         CHO       H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  468                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   469                                                                               "     "        COCH.sub.3                                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  470                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   471                                                                               "     "        Cyclopropyl                                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  472                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   473                                                                               "     "        COCH.sub.2 Cl                                                                            H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  474                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   475                                                                               "     "        COCF.sub.3                                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  476                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   477                                                                               "     "        COOCH.sub.3                                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  478                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   479                                                                               "     "        COC.sub.6 H.sub.5                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  480                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   481                                                                               "     "        CONHC.sub.2 H.sub.5                                                                      H  OCH.sub.3                                                                            OCH.sub.2                                                                            CH                                  482                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   483                                                                               "     "        CSNHC.sub.2 H.sub.5                                                                      H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  484                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   485                                                                               "     "        SO.sub.2 CH.sub.3                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  486                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   487                                                                               "     "        SO.sub.2 NHCH.sub.3                                                                      H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  488                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   489                                                                               "     "        SO.sub.2 N(CH.sub.3).sub.2                                                               H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  490                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   491                                                                               "     "        SO.sub.2 C.sub.6 H.sub.5                                                                 H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  492                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   493                                                                               CO.sub.2 C.sub.2 H.sub.5                                                             H        CHO       H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  494                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   495                                                                               "     "        COCH.sub.3                                                                               H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  496                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   497                                                                               "     "        SO.sub.2 CH.sub.3                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  498                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   499                                                                               "     CH.sub.3 CHO       H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  500                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   501                                                                               "     "        COCH.sub.3                                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  502                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   503                                                                               "     "        SO.sub.2 CH.sub.3                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  504                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   505                                                                               "     C.sub.2 H.sub.5                                                                         CHO       H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  506                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   507                                                                               "     "        COCH.sub.3                                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  508                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   509                                                                               "     "        SO.sub.2 CH.sub.3                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  510                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   511                                                                               "     OH       CHO       H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  512                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   513                                                                               "     "        COCH.sub.3                                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  514                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   515                                                                               "     "        SO.sub.2 CH.sub.3                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  516                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   517                                                                               "     OCH.sub.3                                                                               CHO       H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  518                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   519                                                                               "     "        COCH.sub.3                                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  520                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   521                                                                               COO-n-Bu                                                                             H        CHO       H  "     OMe   CH                                  522                                                                               CONMe.sub.2                                                                          Me       "         H  "     Me    N                                   523                                                                               CONHMe                                                                               H        "         H  "     OMe   CH                                  524                                                                               COSMe Me       CO-Me     H  "     Me    N                                   525                                                                               COOMe n-Bu     CHO       H  "     OMe   CH CH                               526                                                                               "     "        "         H  "     Me    N                                   527                                                                               "     H        "         H  OCH.sub.2 CF.sub.3                                                                   NMe.sub.2                                                                            N                                   528                                                                               "     Me       "         H  "     "     N                                   529                                                                               "     H        CO-Me     H  "     "     N                                   530                                                                               "     Me       "         H  "     "     N                                   531                                                                               "     "        SO.sub.2 CH.sub.3                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  532                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   533                                                                               "                                                                                     ##STR23##         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  534                                                                               "     "                  H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   535                                                                               CO.sub.2 CH.sub.3                                                                    H        COCH.sub.3                                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH Na-Salt:                                                                       270                              __________________________________________________________________________

                                      TABLE 4                                      __________________________________________________________________________      ##STR24##                                                                     CN R.sup.1                                                                              R.sup.4  R.sup.5   R.sup.7                                                                           X     Y     Z  Mp. °C.                   __________________________________________________________________________     1  CO.sub.2 CH.sub.3                                                                    H        CHO       H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  2  "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  3  "     "        "         H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                  4  "     "        "         H  CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                     CH                                  5  "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   6  "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   7  "     "        "         H  OCH.sub.3                                                                            Cl    CH                                  8  "     "        "         H  OCF.sub.2 H                                                                          CH.sub.3                                                                             CH                                  9  "     "        "         H  OCF.sub.2 H                                                                          OCF.sub.2 H                                                                          CH                                  10 "     "        "         H  OCH.sub.3                                                                            Br    CH                                  11 "     "        "         H  OCH.sub.3                                                                            OC.sub.2 H.sub.5                                                                     CH                                  12 "     "        "         H  OCH.sub.3                                                                            SCH.sub.3                                                                            CH                                  13 "     "        "         H  OCH.sub.3                                                                            OC.sub.2 H.sub.5                                                                     N                                   14 "     "        "         H  OCH.sub.3                                                                            OC.sub.3 H.sub.7                                                                     CH                                  15 "     "        "         H  CH.sub.3                                                                             Cl    CH                                  16 "     "        "         H  Cl    OC.sub.2 H.sub.5                                                                     CH                                  17 "     "        "         H  OC.sub.2 H.sub.5                                                                     OC.sub.2 H.sub.5                                                                     CH                                  18 "     "        "         H  C.sub.2 H.sub.5                                                                      OCH.sub.3                                                                            CH                                  19 "     "        "         H  CF.sub.3                                                                             OCH.sub.3                                                                            CH                                  20 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   CH.sub.3                                                                             CH                                  21 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                            CH                                  22 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.2 CF.sub.3                                                                   CH                                  23 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                            N                                   24 "     "        "         H  OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                  CH                                  25 "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  26 "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.3                                                                             N                                   27 "     H        COCH.sub.3                                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  28 "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  29 "     "        "         H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                  30 "     "        "         H  CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                     CH                                  31 "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   32 "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   33 "     "        "         H  OCH.sub.3                                                                            Cl    CH                                  34 "     "        "         H  OCF.sub.2 H                                                                          CH.sub.3                                                                             CH                                  35 "     "        "         H  OCF.sub.2 H                                                                          OCF.sub.2 H                                                                          CH                                  36 "     "        "         H  OCH.sub.3                                                                            Br    CH                                  37 "     "        "         H  OCH.sub.3                                                                            OC.sub.2 H.sub.5                                                                     CH                                  38 "     "        "         H  OCH.sub.3                                                                            SCH.sub.3                                                                            CH                                  39 "     "        "         H  OCH.sub.3                                                                            OC.sub.2 H.sub.5                                                                     N                                   40 "     "        "         H  OCH.sub.3                                                                            OC.sub.3 H.sub.7                                                                     CH                                  41 "     "        "         H  CH.sub.3                                                                             Cl    CH                                  42 "     "        "         H  Cl    OC.sub.2 H.sub.5                                                                     CH                                  43 "     "        "         H  OC.sub.2 H.sub.5                                                                     OC.sub.2 H.sub.5                                                                     CH                                  44 "     "        "         H  C.sub.2 H.sub.5                                                                      OCH.sub.3                                                                            CH                                  45 "     "        "         H  CF.sub.3                                                                             OCH.sub.3                                                                            CH                                  46 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   CH.sub.3                                                                             CH                                  47 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                            CH                                  48 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.2 CF.sub.3                                                                   CH                                  49 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                            N                                   50 "     "        "         H  OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                  CH                                  51 "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  52 "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.3                                                                             N                                   53 "     CH.sub.3 CHO       H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH 150-151                          54 "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  55 "     "        "         H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                  56 "     "        "         H  CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                     CH                                  57 "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   58 "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   59 "     "        "         H  OCH.sub.3                                                                            Cl    CH                                  60 "     "        "         H  OCF.sub.2 H                                                                          CH.sub.3                                                                             CH                                  61 "     "        "         H  OCH.sub.3                                                                            OCF.sub.2 H                                                                          CH                                  62 "     "        "         H  OCH.sub.3                                                                            Br    CH                                  63 "     "        "         H  OCH.sub.3                                                                            OC.sub.2 H.sub.5                                                                     CH                                  64 "     "        "         H  OCH.sub.3                                                                            SCH.sub.3                                                                            CH                                  65 "     "        "         H  OCH.sub.3                                                                            OC.sub.2 H.sub.6                                                                     N                                   66 "     "        "         H  OCH.sub.3                                                                            OC.sub.3 H.sub.7                                                                     CH                                  67 "     "        "         H  CH    Cl    CH                                  68 "     "        "         H  Cl    OC.sub.2 H.sub.5                                                                     CH                                  69 "     "        "         H  OC.sub.2 H.sub.5                                                                     OC.sub.2 H.sub.5                                                                     CH                                  70 "     "        "         H  C.sub.2 H.sub.5                                                                      OCH.sub.3                                                                            CH                                  71 "     "        "         H  CF.sub.3                                                                             OCH.sub.3                                                                            CH                                  72 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   CH.sub.3                                                                             CH                                  73 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                            CH                                  74 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.2 CF.sub.3                                                                   CH                                  75 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                            N                                   76 "     "        "         H  OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                  CH                                  77 "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  78 "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.3                                                                             N                                   79 "     CH.sub.3 COCH.sub.3                                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  80 "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  81 "     "        "         H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                  82 "     "        "         H  CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                     CH                                  83 "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   84 "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   85 "     "        "         H  OCH.sub.3                                                                            Cl    CH                                  86 "     "        "         H  OCF.sub.2 H                                                                          CH.sub.3                                                                             CH                                  87 "     "        "         H  OCF.sub.2 H                                                                          OCF.sub.2 H                                                                          CH                                  88 "     "        "         H  OCH.sub.3                                                                            Br    CH                                  89 "     "        "         H  OCH.sub.3                                                                            OC.sub.2 H.sub.5                                                                     CH                                  90 "     "        "         H  OCH.sub.3                                                                            SCH.sub.3                                                                            CH                                  91 "     "        "         H  OCH.sub.3                                                                            OC.sub.2 H.sub.5                                                                     N                                   92 "     "        "         H  OCH.sub.3                                                                            OC.sub.3 H.sub.7                                                                     CH                                  93 "     "        "         H  CH.sub.3                                                                             Cl    CH                                  94 "     "        "         H  Cl    OC.sub.2 H.sub.5                                                                     CH                                  95 "     "        "         H  OC.sub.2 H.sub.5                                                                     OC.sub.2 H.sub.5                                                                     CH                                  96 "     "        "         H  C.sub.2 H.sub.5                                                                      OCH.sub.3                                                                            CH                                  97 "     "        "         H  CF.sub.3                                                                             OCH.sub.3                                                                            CH                                  98 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   CH.sub.3                                                                             CH                                  99 "     "        "         H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                            CH                                  100                                                                               "     "        "         H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.2 CF                                                                         CH                                  101                                                                               "     "        "         H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                            N                                   102                                                                               "     "        "         H  OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                  CH                                  103                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  104                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.3                                                                             N                                   105                                                                               "     H        SO.sub.2 CH.sub.3                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  106                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  107                                                                               "     "        "         H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                  108                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   109                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   110                                                                               "     "        "         H  OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                           N                                   111                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  112                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.3                                                                             N                                   113                                                                               "     CH.sub.3 SO.sub.2 CH.sub.3                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  114                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  115                                                                               "     "        "         H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                  116                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   117                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   118                                                                               "     "        "         H  OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                           N                                   119                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  120                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.3                                                                             N                                   121                                                                               "     OH       CHO       H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  122                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  123                                                                               "     "        "         H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                  124                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   125                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   126                                                                               "     "        "         H  OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                           N                                   127                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  128                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.3                                                                             N                                   129                                                                               "     OCH.sub.3                                                                               CHO       H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  130                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  131                                                                               "     "        "         H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                  132                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   133                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   134                                                                               "     "        "         H  OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                           N                                   135                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  136                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.3                                                                             N                                   137                                                                               "     OH       COCH.sub.3                                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  138                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  139                                                                               "     "        "         H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                  140                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   141                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   142                                                                               "     "        "         H  OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                           N                                   143                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  144                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.3                                                                             N                                   145                                                                               "     OCH.sub.3                                                                               COCH.sub.3                                                                               H  OCH3  OCH.sub.3                                                                            CH                                  146                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  147                                                                               "     "        "         H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                  148                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   149                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   150                                                                               "     "        "         H  OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                           N                                   151                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  152                                                                               "     "        "         CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.3                                                                             N                                   153                                                                               "     H        COC.sub.2 H.sub.5                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  154                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  155                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   156                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   157                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  158                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  159                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   160                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   161                                                                               "     H        COCH.sub.2 OCH.sub.3                                                                     H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  162                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  163                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   164                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   165                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  166                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  167                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   168                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   169                                                                               "     H        COCO.sub.2 C.sub.2 H.sub.5                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  170                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  171                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   172                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   173                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  174                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  175                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   176                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   177                                                                               "     H        COCF.sub.3                                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  178                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  179                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   180                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   181                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  182                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  183                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   184                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   185                                                                               "     H        COOCH.sub.3                                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  186                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  187                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   188                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   189                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  190                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  191                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   192                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   193                                                                               "     H        CONHC.sub.2 H.sub.5                                                                      H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  194                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  195                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   196                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   197                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  198                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  199                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   200                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   201                                                                               "     H        CSNHC.sub.2 H.sub.5                                                                      H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  202                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  203                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   204                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   205                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  206                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  207                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   208                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   209                                                                               "     H        SO.sub.2 NHCH.sub.3                                                                      H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  210                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  211                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   212                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   213                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  214                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  215                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   216                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   217                                                                               "     H        SO.sub.2 N(CH.sub.3).sub.2                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  218                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  219                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   220                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   221                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  222                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  223                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   224                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   225                                                                               "     CH.sub.2 CH.sub.2 CH.sub.2 CO                                                                     H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  226                                                                               "     "                  H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  227                                                                               "     "                  H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   228                                                                               "     "                  H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   229                                                                               "     CH.sub.2 CH.sub.2 CH.sub.2 SO.sub.2                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  230                                                                               "     "                  H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  231                                                                               "     "                  H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   232                                                                               "     "                  H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   233                                                                               "     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CO                                                            H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  234                                                                               "     "                  H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  235                                                                               "     "                  H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   236                                                                               "     "                  H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   237                                                                               "     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 SO.sub.2                                                      H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  238                                                                               "     "                  H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  239                                                                               "     "                  H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   240                                                                               "     "                  H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   241                                                                               "     CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  242                                                                               "     "                  H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  243                                                                               "     "                  H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   244                                                                               "     "                  H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   245                                                                               "     H        COC.sub.3 H.sub.7                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  246                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  247                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   248                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   249                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  250                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  251                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   252                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   253                                                                               "     H        COCH.sub.2 Cl                                                                            H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  254                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  255                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   256                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   257                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  258                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  259                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   260                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   261                                                                               "     H        COCHCl.sub.2                                                                             H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  262                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  263                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   264                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   265                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  266                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  267                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   268                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   269                                                                               "     H        COCCl.sub.3                                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  270                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  271                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   272                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   273                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  274                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  275                                                                               "     "        "         N  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   276                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   277                                                                               "     H        COCHCH.sub.2                                                                             H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  278                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  279                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   280                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   281                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  282                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  283                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   284                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   285                                                                               "     H        COCCH     H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  286                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  287                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   288                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   289                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  290                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  291                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   292                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   293                                                                               "     H        COC.sub.6 H.sub.5                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  294                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  295                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   296                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   297                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  298                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  299                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   300                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   301                                                                               "     SO.sub.2 C.sub.6 H.sub.5                                                                SO.sub.2 C.sub.6 H.sub.5                                                                 H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  302                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  303                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   304                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   305                                                                               "     SO.sub.2 CH.sub.3                                                                       SO.sub.2 CH.sub.3                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  306                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  307                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   308                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   309                                                                               "     H        COCH.sub.2 Br                                                                            H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  310                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   311                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  312                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   313                                                                               "     H        COCH.sub.2 F                                                                             H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  314                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   315                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  316                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   317                                                                               "     H        COCH.sub.2 CCH                                                                           H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  318                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   319                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  320                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   321                                                                               "     H        COCO.sub.2 CH.sub.3                                                                      H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  322                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   323                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  324                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   325                                                                               "     H        CO.sub.2 C.sub.2 H.sub.5                                                                 H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  326                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   327                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  328                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   329                                                                               "     H        COSCH.sub.3                                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  330                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   331                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  332                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   333                                                                               "     H        CSOCH.sub.3                                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  334                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   335                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  336                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   337                                                                               "     H        CSSCH.sub.3                                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  338                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   339                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  340                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   341                                                                               "     H        COCH(CH.sub.3).sub.2                                                                     H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  342                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   343                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  344                                                                               "     "        "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  345                                                                               "     H        COC(CH.sub.3).sub.3                                                                      H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  346                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   347                                                                               "     CH.sub.3 "         N  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  348                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   349                                                                               "     H        CO-Cyclopropyl                                                                           H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  350                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   351                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  352                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   353                                                                               "     H        CO-Cyclobutyl                                                                            H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  354                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   355                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  356                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   357                                                                               "     H        CO-Cyclopentyl                                                                           H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  358                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   359                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  360                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   361                                                                               "     H        CO-Cyclohexyl                                                                            H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  362                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   363                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  364                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   365                                                                               "     H        CONHCH.sub.2 CH.sub.2 Cl                                                                 H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  366                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   367                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  368                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   369                                                                               "     H        CSNHCH.sub.2 CH.sub.2 Cl                                                                 H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  370                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   371                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  372                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   373                                                                               "     H        CONH-n-C.sub.4 H.sub.9                                                                   H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  374                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   375                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  376                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   377                                                                               "     H        CSNHCH.sub.3                                                                             H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  378                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   379                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  380                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   381                                                                               "     H        CSNHCH.sub.2 CHCH.sub.2                                                                  H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  382                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   383                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  384                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   385                                                                               "     CH.sub.3 CSNHCH.sub.2 COCH.sub.3                                                                  H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  386                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   387                                                                               "     CH.sub.3 CSNHCH.sub.2 COC.sub.2 H.sub.5                                                           H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  388                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   389                                                                               "     CH.sub.3 CONHCH.sub.2 COCH.sub.3                                                                  H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  390                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   391                                                                               "     CH.sub.3 CONHCH.sub.2 COC.sub.2 H.sub.5                                                           H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  392                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   393                                                                               "     CONHCH.sub.2 CO    H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  394                                                                               "     "                  H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   395                                                                               "     H        SO.sub.2 CH.sub.2 F                                                                      H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  396                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   397                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  398                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   399                                                                               "     H        SO.sub.2 CF.sub.3                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  400                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   401                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  402                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   403                                                                               "     H        SO.sub.2 C.sub.2 H.sub.5                                                                 H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  404                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   405                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  406                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   407                                                                               "     H        SO.sub.2 -n-C.sub.3 H.sub.7                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  408                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   409                                                                               "     CH.sub.3 "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  410                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   411                                                                               "     OH       COC.sub.2 H.sub.5                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  412                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   413                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.                             414                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   415                                                                               "     OH       COCH.sub.2 Cl                                                                            H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  416                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   417                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  418                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   419                                                                               "     OH       COCF.sub.3                                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  420                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   421                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  422                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   423                                                                               "     OH       COCH.sub.2 OCH.sub.3                                                                     H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  424                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   425                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  426                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   427                                                                               "     OH       COCO.sub.2 C.sub.2 H.sub.5                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  428                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   429                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  430                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   431                                                                               "     OH       COOCH.sub.3                                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  432                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   433                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  434                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   435                                                                               "     OH       Cyclopropyl                                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  436                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   437                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  438                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   439                                                                               "     OH       COC.sub.6 H.sub.5                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  440                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   441                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  442                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   443                                                                               "     OH       COCH(CH.sub.3).sub.2                                                                     H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  444                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   445                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  446                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   447                                                                               "     OH       COCHCH.sub.2                                                                             H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  448                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   449                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  450                                                                               "     "        "         H  CH.sub.3                                                                             CH.sub.3                                                                             N                                   451                                                                               "     OH       COCCH     H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  452                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   453                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  454                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   455                                                                               "     OH       SO.sub.2 CH.sub.3                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  456                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   457                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  458                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   459                                                                               "     OH       SO.sub.2 NHCH.sub.3                                                                      H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  460                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   461                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  462                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   463                                                                               "     OH       SO.sub.2 N(CH.sub.3).sub.2                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  464                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   465                                                                               "     OCH.sub.3                                                                               "         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  466                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   467                                                                               "     C.sub.2 H.sub.5                                                                         CHO       H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  468                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   469                                                                               "     "        COCH.sub.3                                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  470                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   471                                                                               "     "        Cyclopropyl                                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  472                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   473                                                                               "     "        COCH.sub.2 Cl                                                                            H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  474                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   475                                                                               "     "        COCF.sub.3                                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  476                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   477                                                                               "     "        COOCH.sub.3                                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  478                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   479                                                                               "     "        COC.sub.6 H.sub.5                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  480                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   481                                                                               "     "        CONHC.sub.2 H.sub.5                                                                      H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  482                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   483                                                                               "     "        CSNHC.sub.2 H.sub.5                                                                      H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  484                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   485                                                                               "     "        SO.sub.2 CH.sub.3                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  486                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   487                                                                               "     "        SO.sub.2 N(CH.sub.3).sub.2                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  488                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   489                                                                               "     "        SO.sub.2 N(CH.sub.3).sub.2                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  490                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   491                                                                               "     "        SO.sub.2 C.sub.6 H.sub.5                                                                 H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  492                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   493                                                                               CO.sub.2 C.sub.2 H.sub.5                                                             H        CHO       H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  494                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   495                                                                               "     "        COCH.sub.3                                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  496                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   497                                                                               "     "        SO.sub.2 CH.sub.3                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  498                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   499                                                                               "     CH.sub.3 CHO       H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  500                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   501                                                                               "     "        COCH.sub.3                                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  502                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   503                                                                               "     "        SO.sub.2 CH.sub.3                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  504                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   505                                                                               "     C.sub.2 H.sub.5                                                                         CHO       H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  506                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   507                                                                               "     "        COCH.sub.3                                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  508                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   509                                                                               "     "        SO.sub.2 CH.sub.3                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  510                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   511                                                                               "     OH       CHO       H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  512                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   513                                                                               "     "        COCH.sub.3                                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  514                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   515                                                                               "     "        SO.sub.2 CH.sub.3                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  516                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   517                                                                               "     OCH.sub.3                                                                               CHO       H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  518                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   519                                                                               "     "        COCH.sub.3                                                                               H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  520                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   521                                                                               COO-n-Bu                                                                             H        CHO       H  "     OMe   CH                                  522                                                                               CONMe.sub.2                                                                          Me       "         H  "     Me    N                                   523                                                                               CONHMe                                                                               H        "         H  "     OMe   CH                                  524                                                                               COSMe Me       CO-Me     H  "     Me    N                                   525                                                                               CO-OMe                                                                               n-Bu     CHO       H  "     OMe   CH                                  526                                                                               "     n-Bu     "         H  "     Me    N                                   527                                                                               "     H        "         H  OCH.sub.2 CF.sub.3                                                                   NMe.sub.2                                                                            N                                   528                                                                               "     Me       "         H  "     "     N                                   529                                                                               "     H        COMe      H  "     "     N                                   530                                                                               "     Me       "         H  "     "     N                                   531                                                                               "     "        SO.sub.2 CH.sub.3                                                                        H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  532                                                                               "     "        "         H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   533                                                                               CO.sub.2 CH.sub.3                                                                     ##STR25##         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  534                                                                               "     "                  H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                   __________________________________________________________________________

B. Formulation Examples

a) A dusting agent is obtained by mixing 10 parts by weight of a compound of the formula (I) and 90 parts by weight of talc as inert substance and comminuting the mixture in a hammer mill.

b) A wettable powder which is readily dispersible in water is obtained by mixing 25 parts by weight of a compound of the formula (I), 64 parts by weight of kaolin-containing quartz as inert substance, 10 parts by weight of potassium ligninsulfonate and 1 part by weight of sodium oleoylmethyltaurinate as the wetting and dispersing agent, and grinding the mixture in a pinned-disk mill.

c) A dispersion concentrate which is readily dispersible in water is obtained by mixing 20 parts by weight of a compound of the formula (I) with 6 parts by weight of alkylphenol polyglycol ether (Triton® X 207), 3 parts by weight of isotridecanol polyglycol ether (8 EO) and 71 parts by weight of paraffinic mineral oil (boiling range, for example, about 255° to above 277° C.), and grinding the mixture in a ball mill to a fineness of below 5 microns.

d) An emulsifiable concentrate is obtained from 15 parts by weight of a compound of the formula (I), 75 parts by weight of cyclohexanone as solvent and 10 parts by weight of ethoxylated nonylphenol as emulsifier.

e) Water-dispersible granules are obtained by mixing

    ______________________________________                                         75      parts by weight                                                                              of a compound of the                                                           formula (I),                                             10      parts by weight                                                                              of calcium lignin-                                                             sulfonate,                                               5       parts by weight                                                                              of sodium lauryl                                                               sulfate                                                  3       parts by weight                                                                              of polyvinyl alcohol and                                 7       parts by weight                                                                              of kaolin,                                               ______________________________________                                    

grinding the mixture in a pinned-disk mill and granulating the powder in a fluidized bed by spraying on water as granulation liquid.

f) Water-dispersible granules are also obtained by homogenizing and precomminuting, in a colloid mill,

25 parts by weight of a compound of the formula (I),

    ______________________________________                                         5       parts by weight                                                                              of sodium 2,2'-                                                                dinaphthylmethane-6,6'-                                                        disulphonate,                                            2       parts by weight                                                                              of sodium oleoylmethyl-                                                        taurinate,                                               1       part by weight                                                                               of polyvinyl alcohol,                                    17      parts by weight                                                                              of calcium carbonate and                                 50      parts by weight                                                                              of water,                                                ______________________________________                                    

then grinding the mixture in a bead mill, atomizing the resulting suspension in a spray tower using a single-substance nozzle, and drying the product.

C. Biological Examples

1. Pre-emergence effect on weeds

Seeds or rhizome pieces of monocotyledon and dicotyledon weed plants are placed in sandy loam soil in plastic pots and covered with soil. The compounds of the formula (I) according to the invention or their salts, which were formulated in the form of wettable powders or emulsion concentrates, are then applied to the surface of the soil cover in the form of an aqueous suspension or emulsion at an application rate of 600 to 800 l of water/ha (converted), in various dosages.

After the treatment, the pots are placed in a greenhouse and kept under good growth conditions for the weeds. After the test plants have emerged the damage to the plants or the negative effect on emergence is scored visually after a test period of 3 to 4 weeks by comparison with untreated controls. As shown by the test results, the compounds according to the invention have a good herbicidal pre-emergence activity against a broad range of grass weeds and dicotyledon weeds. For example, the compounds of Examples 1, 27, 53 to 55, 58, 59, 79, 105, 113, 129, 145, 153, 177, 181, 185, 189, 213, 217, 221, 253, 257, 421, 425, 429, 433, 437, 445, 457, 461, 465, 467, 485, 487, 535 to 543, 547, 551 to 559, 562, 563 and 565 to 578 from Table 1 and Examples 1, 27, 53, 79, 153, 161, 169, 177, 181, 185, 253, 261, 269, 341, 349, 365 and 373 from Table 2 and Examples 27 and 535 from Table 3 and Example 53 from Table 4 have a good herbicidal pre-emergence action against nuisance plants such as Sinapis alba, Stellaria media, Chrysanthemum segetum and Lolium multiflorum when applied at a rate of from 0.3 kg to 0.005 kg of active substance per hectare.

2. Post-emergence effect on weeds

Seeds or rhizome pieces of monocotyledon and dicotyledon weeds are placed in sandy loam soil in plastic pots, covered with soil and grown in a greenhouse under good growth conditions. Three weeks after sowing, the test plants are treated at the three-leaf stage. The compounds of the formula (I) according to the invention or their salts, which were formulated as wettable powders or as emulsion concentrates, are sprayed in various dosages at an application rate of from 600 to 800 l of water/ha (converted) onto the green parts of the plants and, after the test plants have remained in the greenhouse for about 3 to 4 weeks under ideal growth conditions, the action of the preparations is scored visually by comparison with untreated controls. The agents according to the invention also have a good herbicidal post-emergence action against a broad range of economically important grass weeds and dicotyledon weeds. For example, the compounds of Examples 1, 27, 53 to 55, 58, 59, 79, 105, 113, 129, 145, 153, 177, 181, 185, 189, 213, 217, 221, 253, 257, 421, 425, 429, 433, 437, 445, 457, 461, 465, 467, 485, 487, 535 to 543, 547, 551 to 559, 562, 563 and 565 to 578 from Table 1 and Examples 1, 27, 53, 79, 153, 161, 169, 177, 181, 185, 253, 261, 269, 341, 349, 365 and 373 from Table 2 and Examples 27 and 535 from Table 3 and Example 53 from Table 4 have a very good herbicidal post-emergence action against nuisance plants such as Sinapis alba, Stellaria media, Chrysanthemum segetum and Lolium multiflorum when applied at a rate of from 0.3 kg to 0.005 kg of active substance per hectare.

3. Tolerance by crop plants

In further greenhouse experiments, seeds of a substantial number of crop plants and weeds were placed in sandy loam soil and covered with soil.

Some of the pots were treated immediately as described under 1., and the remaining pots were placed in a greenhouse until the plants had developed two to three true leaves and were then sprayed with various dosages of the substances of the formula (I) according to the invention or their salts, as described under 2.

Visual scoring four to five weeks after the application and after the plants had been in the greenhouse revealed that the compounds according to the invention did not inflict any damage on dicotyledon crops such as, for example, soya, cotton, oilseed rape, sugar beet end potatoes when used pre- and post-emergence, even at high dosages of active substance. Moreover, some substances even left Gramineae crops such as barley, wheat, rye, sorghum millets, maize or rice unharmed. The compounds of the formula (I) or salts thereof therefore have a high selectivity when used for controlling unwanted plant growth in agricultural crops. 

We claim:
 1. A compound of the formula (I) or salts thereof, ##STR26## in which R¹ is CO--Q--R⁸,R² and R³ independently of one another are H or (C₁ -C₄)alkyl, R⁴ is H, (C₁ -C₄)alkyl which is unsubstituted or is substituted by one or more radicals from the group consisting of halogen, (C₁ -C₄)alkoxy, (C₁ -C₄)alkylthio, (C₁ -C₄)alkylsulfinyl, (C₁ -C₄)alkylsulfonyl, [(C₁ -C₄)alkoxy]carbonyl and CN, or is (C₃ -C₆)alkenyl which is unsubstituted or is substituted by one or more halogen atoms, or is (C₃ -C₆)alkynyl which is unsubstituted or is substituted by one or more halogen atoms, or is hydroxyl, (C₁ -C₄)alkoxy, [(C₁ -C₄)alkyl]carbonyl or (C₁ -C₄)alkylsulfonyl, each of the three latter radicals being unsubstituted or substituted in the alkyl moiety by one or more halogen atoms or by (C₁ -C₄)alkoxy or (C₁ -C₄)alkylthio, or is phenylsulfonyl in which the phenyl radical is unsubstituted or substituted, and R⁵ is (C₁ -C₄)alkylsulfonyl or (C₃ -C₆)alkenylsulfonyl, each of the two latter radicals being unsubstituted or substituted by one or more halogen atoms or by (C₁ -C₄)alkoxy or (C₁ -C₄)alkylthio, or is phenylsulfonyl or phenylcarbonyl, the phenyl radical in each of the two latter radicals being unsubstituted or substituted, or is mono- or di-[(C₁ -C₄)alkyl]aminosulfonyl or [(C₁ -C₆)alkyl]carbonyl, each of the three latter radicals being unsubstituted or substituted by one or more radicals from the group consisting of halogen, (C₁ -C₄)alkoxy, (C₁ -C₄)alkylthio, (C₁ -C₄)alkylsulfinyl, (C₁ -C₄)alkylsulfonyl, [(C₁ -C₄)alkyl]carbonyl, [(C₁ -C₄)alkoxy]carbonyl and CN, or is formyl, a group of the formula --CO--CO--R' in which R'═H, OH, (C₁ -C₄)alkoxy or (C₁ -C₄)alkyl, or is [(C₃ -C₆)cycloalkyl]carbonyl, [(C₂ -C₆)alkenyl]carbonyl or [(C₂ -C₆)alkynyl]carbonyl, each of the three latter radicals being unsubstituted or substituted by one or more halogen atoms, or is a group of the formula ##STR27## with the exception of the definition R⁵ =unsubstituted [(C₁ -C₆)Alkyl]-carbonyl, if the radical of the formula --CR² R³ --NR⁴ R⁵ is in para-position of the SO₂ group at the phenyl ring; or R⁴ and R⁵ together are a chain of the formula (--CH₂)_(m) B² -- or --B¹ --(CH₂)_(m1) B² --, the chain being unsubstituted or substituted by one or more (C₁ -C₃)alkyl radicals and m being 3 or 4 or m¹ being 2 or 3, and W is an oxygen or sulfur atom, B¹ and B² independently of one another are SO₂ or CO, Q is O, S or --NR¹³, T is O or S, R⁶ is H, (C₁ -C₄)alkyl, (C₁ -C₄)alkoxy, [(C₁ -C₄)alkyl]carbonyl or [(C₁ -C₄)alkoxy]carbonyl, each of the 4 latter radicals being unsubstituted or substituted in the alkyl moiety by one or more halogen atoms, or is halogen, NO₂ or CN, R⁷ is H or CH₃, R⁸ is H, (C₁ -C₄)alkyl, (C₃ -C₄)alkenyl or (C₃ -C₄)alkynyl, each of the three latter radicals being unsubstituted or substituted by one or more radicals from the group consisting of halogen, (C₁ -C₄)alkoxy, (C₁ -C₄)alkylthio, [(C₁ -C₄)alkyl]carbonyl and [(C₁ -C₄)alkoxy]carbonyl, R⁹ is (C₁ -C₄)alkyl, (C₃ -C₄)alkenyl or (C₃ -C₄)alkynyl, each of the three latter radicals being unsubstituted or substituted by one or more radicals from the group consisting of halogen, (C₁ -C₄)alkoxy, (C₁ -C₄)alkylthio, [(C₁ -C₄)alkyl]carbonyl and [(C₁ -C₄)alkoxy]carbonyl, R¹⁰ and R¹¹ independently of one another are H, (C₁ -C₄)alkyl, (C₃ -C₄)alkenyl or (C₃ -C₄)alkynyl, each of the three latter radicals being unsubstituted or substituted by one or more radicals from the group consisting of halogen, (C₁ -C₄)alkoxy, (C₁ -C₄)alkylthio, [(C₁ -C₄)alkyl]carbonyl and [(C₁ -C₄)alkoxy]carbonyl, the radicals R¹² together with the nitrogen atom are a heterocyclic ring having 5 or 6 ring members, selected from the group consisting of 1-pyrrolidinyl, 1-piperidinyl and 4-morpholinyl, which is unsubstituted or is substituted by (C₁ -C₄)alkyl, R¹³ is H, (C₁ -C₄)alkyl, (C₃ -C₄)alkenyl or (C₃ -C₄)alkynyl, each of the three latter radicals being unsubstituted or substituted by one or more radicals from the group consisting of halogen, (C₁ -C₄)alkoxy and (C₁ -C₄)alkylthio, A is a radical of the formula ##STR28## one of the radicals X and Y is hydrogen, halogen, (C₁ -C₃)alkyl or (C₁ -C₃)alkoxy, the two latter radicals being unsubstituted or being mono- or polysubstituted by halogen or monosubstituted by (C₁ -C₃)alkoxy, and the other of the radicals X and Y is hydrogen, (C₁ -C₃)alkyl, (C₁ -C₃)alkoxy or (C₁ -C₃)alkylthio, the three latter alkyl-containing radicals being unsubstituted or mono- or polysubstituted by halogen or mono- or disubstituted by (C₁ -C₃)alkoxy or (C₁ -C₃)alkylthio, or is a radical of the formula NR¹⁴ R¹⁵, (C₃ -C₆)cycloalkyl, (C₂ -C₄)alkenyl, (C₂ -C₄)alkynyl, (C₃ -C₄)alkenyloxy or (C₃ -C₄)alkynyloxy, Z is CH, R¹⁴ and R¹⁵ independently of one another are H, (C₁ -C₃)alkyl or (C₃ -C₄)alkenyl.
 2. A compound or salt thereof as claimed in claim 1, whereinR⁴ is H, (C₁ -C₄)alkyl, which is unsubstituted or is substituted by one or more radicals from the group consisting of halogen, (C₁ -C₄)alkoxy, (C₁ -C₄)alkylthio, (C₁ -C₄)alkylsulfonyl, [(C₁ -C₄)alkoxy]carbonyl and CN, or is (C₃ -C₄)alkenyl, (C₃ -C₄)alkynyl, hydroxyl, (C₁ -C₄)alkoxy, [(C₁ -C₄)alkyl]carbonyl or (C₁ -C₄)alkylsulfonyl, each of the five latter radicals being unsubstituted or substituted in the alkyl moiety by one or more halogen atoms, or is phenylsulfonyl in which the phenyl radical is unsubstituted or is substituted by one or more radicals from the group consisting of halogen, (C₁ -C₄)alkyl and (C₁ -C₄)alkoxy, and R⁵ is (C₁ -C₄)alkylsulfonyl, (C₁ -C₄)haloalkylsulfonyl, phenylsulfonyl or phenylcarbonyl, the phenyl radical in the two latter radicals being unsubstituted or substituted by one or more radicals from the group consisting of halogen, (C₁ -C₄)alkyl and (C₁ -C₄)alkoxy, or is mono- or di-[(C₁ -C₄)alkyl]aminosulfonyl, [(C₁ -C₆)alkyl]carbonyl which is unsubstituted or is substituted by one or more halogen atoms or by (C₁ -C₄)alkoxy or (C₁ -C₄)alkylthio, or is formyl, OHC--CO--, 2-oxo-(C₃ -C₅)alkanoyl, [(C₁ -C₄)alkoxy]oxalyl, [(C₃ -C₆)cycloalkyl]carbonyl, [(C₂ -C₄)alkenyl]carbonyl or [(C₂ -C₄)alkynyl]carbonyl or is a group of the formula ##STR29## W is O or S, R⁶ is H, (C₁ -C₄)alkyl, (C₁ -C₄)haloalkyl, (C₁ -C₄)alkoxy, (C₁ -C₄)haloalkoxy or halogen, R⁸ is at each occurrence (C₁ -C₄)alkyl which is unsubstituted or is substituted by one or more halogen atoms, or is (C₃ -C₄)alkenyl or (C₃ -C₄)alkynyl, R⁹ is H, (C₁ -C₄)alkyl which is unsubstituted or is substituted by one or more halogen atoms or by (C₁ -C₄)alkoxy, (C₁ -C₄)alkylthio, [(C₁ -C₄)alkoxy]carbonyl and [(C₁ -C₄)alkyl]carbonyl, R¹⁰ and R¹¹ independently of one another are H, (C₁ -C₄)alkyl which is unsubstituted or is substituted by one or more halogen atoms, or are (C₃ -C₄)alkenyl or (C₃ -C₄)alkynyl, at least one of the radicals R¹⁰ and R¹¹ being different from hydrogen, the radicals R¹² together with the nitrogen atom are a heterocyclic ring having 5 or 6 ring members, selected from the group consisting of 1-pyrrolidinyl, 1-piperidinyl and 4-morpholinyl, and R¹³ is at each occurrence H, (C₁ -C₄)alkyl which is unsubstituted or is substituted by one or more halogen atoms, or is (C₃ -C₄)alkenyl or (C₃ -C₄)-alkynyl.
 3. A compound or salt thereof as claimed in claim 1, whereinR⁴ is H, (C₁ -C₄)alkyl, hydroxyl or (C₁ -C₄)alkoxy, R⁵ is (C₁ -C₄)alkylsulfonyl, CHO, [(C₁ -C₄)alkyl]carbonyl which is unsubstituted or is substituted by one or more halogen atoms, or is [(C₁ -C₄)alkoxy]oxalyl, [(C₃ -C₆)cycloalkyl]carbonyl or a group of the formula ##STR30## in which W, T and R⁹ to R¹² are as defined above for formula (I), R⁶ is H, (C₁ -C₃)alkyl, (C₁ -C₃)alkoxy or halogen, A is a radical of the formula ##STR31## Z is CH, and one of the radicals X and Y is halogen, (C₁ -C₂)alkyl, (C₁ -C₂)alkoxy, OCF₂ H, CF₃ or OCH₂ CF₃ and the other of the radicals X and Y is (C₁ -C₂)alkyl, (C₁ -C₂)alkoxy or (C₁ -C₂)haloalkoxy.
 4. A compound of formula (I) or salts thereof as claimed in claim 1, wherein:R² is H, R³ is H, R⁴ is H or (C₁ -C₄)alkyl, R⁵ is (C₁ -C₄)alkylsulfonyl, [(C₁ -C₄)alkyl]-carbonyl, a group of the formula --C(═W)--T--R⁸ in which W is O or S; T is O or S, and R⁸ is (C₁ -C₄)alkyl, (C₃ -C₄)alkenyl or (C₃ -C₄)alkynyl, R⁶ is H, R⁷ is H, A is a group of the formula: ##STR32## Z is CH, X is methyl, methoxy or chloro, and Y is methyl or methoxy.
 5. A compound of formula (I) or salts thereof as claimed in claim 4, wherein R⁵ is (C₁ -C₄)alkylsulfonyl.
 6. A compound of formula (I) or salts thereof as claimed in claim 4, wherein R⁵ is [(C₁ -C₄)alkyl]-carbonyl.
 7. A compound of formula (I) or salts thereof as claimed in claim 4, wherein:R⁵ is a group of the formula --CO--O--R⁹ and R⁹ is (C₁ -C₄)alkyl.
 8. A herbicidal or plant growth-regulating composition, which comprises one or more compounds of the formula (I) or salt thereof as claimed in claim 1 and formulation auxiliaries which are conventional in crop protection.
 9. A method for controlling nuisance plants or for regulating the growth of plants, which comprises applying an effective quantity of one or more compounds of the formula (I) or of a salt thereof as claimed in claim 1 to the nuisance plants or plants, the plant seeds or the area on which they are growing. 